Literature DB >> 25433271

Diverse roles of LPA signaling in the intestinal epithelium.

C Chris Yun1, Ajay Kumar2.   

Abstract

Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signaling in the intestinal tract.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Colon cancer; Inflammation; Intestine; Lysophosphatidic acid

Mesh：

Substances：

Year:  2014        PMID： 25433271      PMCID： PMC4408216          DOI： 10.1016/j.yexcr.2014.11.013

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  10 in total

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Authors:  Carsten Gram Hansen; Toshiro Moroishi; Kun-Liang Guan
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2.  Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats.

Authors:  Toshihiko Tsutsumi; Manami Inoue; Yoko Okamoto; Akira Ishihara; Akira Tokumura
Journal:  Dig Dis Sci       Date:  2017-01-03       Impact factor: 3.199

Review 3.  The recycling regulation of sodium-hydrogen exchanger isoform 3(NHE3) in epithelial cells.

Authors:  Ling Ran; Tao Yan; Yiling Zhang; Zheng Niu; Zifei Kan; Zhenhui Song
Journal:  Cell Cycle       Date:  2021-11-25       Impact factor: 4.534

4.  LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.

Authors:  Pradeep K Shukla; Avtar S Meena; Ruchika Gangwar; Erzsebet Szabo; Andrea Balogh; Sue Chin Lee; Alain Vandewalle; Gabor Tigyi; RadhaKrishna Rao
Journal:  FASEB J       Date:  2020-07-12       Impact factor: 5.191

5.  HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5.

Authors:  Yi Ran No; Sei-Jung Lee; Ajay Kumar; C Chris Yun
Journal:  PLoS One       Date:  2015-09-09       Impact factor: 3.240

6.  Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity.

Authors:  Chi Zhang; Weiyun Li; Xiaobo Lei; Zhenfei Xie; Linlin Qi; Hui Wang; Xia Xiao; Jun Xiao; Yuxiao Zheng; Chen Dong; Xin Zheng; Shiyang Chen; Jianfeng Chen; Bing Sun; Jun Qin; Qiwei Zhai; Jinsong Li; Bin Wei; Jianwei Wang; Hongyan Wang
Journal:  Sci Adv       Date:  2021-09-17       Impact factor: 14.136

7.  Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets.

Authors:  Jacob Tveiten Bjerrum; Yulan Wang; Jingtao Zhang; Lene Buhl Riis; Ole Haagen Nielsen; Jakob Benedict Seidelin
Journal:  Int J Biol Sci       Date:  2022-02-14       Impact factor: 6.580

8.  Selective measurement of NAPE-PLD activity via a PLA1/2-resistant fluorogenic N-acyl-phosphatidylethanolamine analog.

Authors:  Jonah E Zarrow; Jianhua Tian; Brendan Dutter; Kwangho Kim; Amanda C Doran; Gary A Sulikowski; Sean S Davies
Journal:  J Lipid Res       Date:  2021-11-26       Impact factor: 5.922

9.  LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.

Authors:  Mohammad M Ahmadzai; Jonathon L McClain; Christine Dharshika; Luisa Seguella; Fiorella Giancola; Roberto De Giorgio; Brian D Gulbransen
Journal:  J Clin Invest       Date:  2022-02-15       Impact factor: 14.808

10.  Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD.

Authors:  Thomas Lee; Thomas Clavel; Kirill Smirnov; Annemarie Schmidt; Ilias Lagkouvardos; Alesia Walker; Marianna Lucio; Bernhard Michalke; Philippe Schmitt-Kopplin; Richard Fedorak; Dirk Haller
Journal:  Gut       Date:  2016-02-04       Impact factor: 23.059
  10 in total

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