Lisa M Chin1, Randall Eugene Keyser2, John Dsurney3, Leighton Chan3. 1. Department of Rehabilitation Science, George Mason University, Fairfax, VA; Rehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD. Electronic address: lchin2@gmu.edu. 2. Department of Rehabilitation Science, George Mason University, Fairfax, VA; Rehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD. 3. Rehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD; Center for Neuroscience and Regenerative Medicine, Bethesda, MD.
Abstract
OBJECTIVE: To examine cognitive function in individuals with traumatic brain injury (TBI) prior to and after participation in an aerobic exercise training program. DESIGN: Pre-post intervention study. SETTING: Medical research center. PARTICIPANTS: Volunteer sample of individuals (N=7) (age, 33.3±7.9y) with chronic nonpenetrating TBI (injury severity: 3=mild, 4=moderate; time since most current injury: 4.0±5.5y) who were ambulatory. INTERVENTION: Twelve weeks of supervised vigorous aerobic exercise training performed 3 times a week for 30 minutes on a treadmill. MAIN OUTCOME MEASURES: Cognitive function was assessed using the Trail Making Test Part A (TMT-A), Trail Making Test Part B (TMT-B), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sleep quality and depression were measured with the Pittsburgh Sleep Quality Index (PSQI) and Beck Depression Inventory, version 2 (BDI-II). Indices of cardiorespiratory fitness were used to examine the relation between improvements in cognitive function and cardiorespiratory fitness. RESULTS: After training, improvements in cognitive function were observed with greater scores on the TMT-A (10.3±6.8; P=.007), TMT-B (9.6±7.0; P=.011), and RBANS total scale (13.3±9.3; P=.009). No changes were observed in measures of the PSQI and BDI-II. The magnitude of cognitive improvements was also strongly related to the gains in cardiorespiratory fitness. CONCLUSIONS: These findings suggest that vigorous aerobic exercise training may improve specific aspects of cognitive function in individuals with TBI and cardiorespiratory fitness gains may be a determinant of these improvements.
OBJECTIVE: To examine cognitive function in individuals with traumatic brain injury (TBI) prior to and after participation in an aerobic exercise training program. DESIGN: Pre-post intervention study. SETTING: Medical research center. PARTICIPANTS: Volunteer sample of individuals (N=7) (age, 33.3±7.9y) with chronic nonpenetrating TBI (injury severity: 3=mild, 4=moderate; time since most current injury: 4.0±5.5y) who were ambulatory. INTERVENTION: Twelve weeks of supervised vigorous aerobic exercise training performed 3 times a week for 30 minutes on a treadmill. MAIN OUTCOME MEASURES: Cognitive function was assessed using the Trail Making Test Part A (TMT-A), Trail Making Test Part B (TMT-B), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sleep quality and depression were measured with the Pittsburgh Sleep Quality Index (PSQI) and Beck Depression Inventory, version 2 (BDI-II). Indices of cardiorespiratory fitness were used to examine the relation between improvements in cognitive function and cardiorespiratory fitness. RESULTS: After training, improvements in cognitive function were observed with greater scores on the TMT-A (10.3±6.8; P=.007), TMT-B (9.6±7.0; P=.011), and RBANS total scale (13.3±9.3; P=.009). No changes were observed in measures of the PSQI and BDI-II. The magnitude of cognitive improvements was also strongly related to the gains in cardiorespiratory fitness. CONCLUSIONS: These findings suggest that vigorous aerobic exercise training may improve specific aspects of cognitive function in individuals with TBI and cardiorespiratory fitness gains may be a determinant of these improvements.
Authors: Lisa M K Chin; Leighton Chan; Joshua G Woolstenhulme; Eric J Christensen; Christian N Shenouda; Randall E Keyser Journal: J Head Trauma Rehabil Date: 2015 Nov-Dec Impact factor: 2.710
Authors: Patrick J Smith; James A Blumenthal; Benson M Hoffman; Harris Cooper; Timothy A Strauman; Kathleen Welsh-Bohmer; Jeffrey N Browndyke; Andrew Sherwood Journal: Psychosom Med Date: 2010-03-11 Impact factor: 4.312
Authors: Carol Ewing Garber; Bryan Blissmer; Michael R Deschenes; Barry A Franklin; Michael J Lamonte; I-Min Lee; David C Nieman; David P Swain Journal: Med Sci Sports Exerc Date: 2011-07 Impact factor: 5.411
Authors: Beeta Y Homaifar; Lisa A Brenner; Peter M Gutierrez; Jeri F Harwood; Caitlin Thompson; Christopher M Filley; James P Kelly; Lawrence E Adler Journal: Arch Phys Med Rehabil Date: 2009-04 Impact factor: 3.966
Authors: Emma C Lape; Jeffrey N Katz; Elena Losina; Hannah M Kerman; Marissa A Gedman; Cheri A Blauwet Journal: PM R Date: 2017-10-27 Impact factor: 2.298
Authors: Ali A Weinstein; Lisa M K Chin; John Collins; Divya Goel; Randall E Keyser; Leighton Chan Journal: J Head Trauma Rehabil Date: 2017 May/Jun Impact factor: 2.710
Authors: Teodor T Postolache; Abhishek Wadhawan; Adem Can; Christopher A Lowry; Margaret Woodbury; Hina Makkar; Andrew J Hoisington; Alison J Scott; Eileen Potocki; Michael E Benros; John W Stiller Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472