Rubén Díez Rodríguez1, María D Ballesteros Pomar2, Alicia Calleja Fernández1, Sara Calleja Antolin3, Isidoro Cano Rodríguez1, Pedro Linares Torres4, Francisco Jorquera Plaza4, José Luis Olcoz Goñi2. 1. High Risk Obesity Unit, Complejo Asistencial Universitario de León. Endocrinology and Nutrition Department, Complejo Asistencial Universitario de León.. rudiro81@gmail.com. 2. High Risk Obesity Unit, Complejo Asistencial Universitario de León.Digestive Disease Department, Complejo Asistencial Universitario de León.. rudiro81@gmail.com. 3. High Risk Obesity Unit, Complejo Asistencial Universitario de León. Immunology Department, Complejo Asistencial Universitario de León. León, Spain.. rudiro81@gmail.com. 4. Digestive Disease Department, Complejo Asistencial Universitario de León.. rudiro81@gmail.com.
Abstract
BACKGROUND: Morbidly obese patients usually present vitamin D deficiency or secondary hyperparathyroidism. Low vitamin D levels have been recently related to non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyse the relationship between vitamin D, bone turnover markers and non-alcoholic fatty liver disease and metabolic syndrome in severely obese patients. METHODS: One hundred and ten patients who underwent bariatric surgery were included. Liver biopsy was taken during surgery. Two univariate analyses were carried out in order to i) analyse the relationship between liver histology and vitamin D-bone turnover markers (intact parathyroid hormone (PTH), osteocalcin and Carboxy-terminal collagen crosslinks) and ii) establish the association between metabolic syndrome components-insulin resistance (HOMA) and vitamin D-bone turnover markers. RESULTS: 70% of the patients had lower levels of vitamin D or secondary hyperparathyroidism. None of the components of liver histology were associated with levels of vitamin D or with bone turnover parameters. Patients with metabolic syndrome showed lower levels of PTH and osteocalcin (72,42 (29,47) vs 61.25(19.59) p-Value: 0.022; 19.79 (10.43) vs 16.87(10.25) p-Value: 0,028, respectively). HOMA was not related to Vitamin D or bone turnover markers. CONCLUSION: Low levels of vitamin D or hyperparathyroidism are common in severely obese patients. Vitamin D and bone metabolism markers were associated neither to NAFLD nor with metabolic syndrome in our series of obese morbid patients. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
BACKGROUND: Morbidly obesepatients usually present vitamin Ddeficiency or secondary hyperparathyroidism. Low vitamin D levels have been recently related to non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyse the relationship between vitamin D, bone turnover markers and non-alcoholic fatty liver disease and metabolic syndrome in severely obesepatients. METHODS: One hundred and ten patients who underwent bariatric surgery were included. Liver biopsy was taken during surgery. Two univariate analyses were carried out in order to i) analyse the relationship between liver histology and vitamin D-bone turnover markers (intact parathyroid hormone (PTH), osteocalcin and Carboxy-terminal collagen crosslinks) and ii) establish the association between metabolic syndrome components-insulin resistance (HOMA) and vitamin D-bone turnover markers. RESULTS: 70% of the patients had lower levels of vitamin D or secondary hyperparathyroidism. None of the components of liver histology were associated with levels of vitamin D or with bone turnover parameters. Patients with metabolic syndrome showed lower levels of PTH and osteocalcin (72,42 (29,47) vs 61.25(19.59) p-Value: 0.022; 19.79 (10.43) vs 16.87(10.25) p-Value: 0,028, respectively). HOMA was not related to Vitamin D or bone turnover markers. CONCLUSION: Low levels of vitamin D or hyperparathyroidism are common in severely obesepatients. Vitamin D and bone metabolism markers were associated neither to NAFLD nor with metabolic syndrome in our series of obese morbid patients. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Yuval A Patel; Ricardo Henao; Cynthia A Moylan; Cynthia D Guy; Dawn L Piercy; Anna Mae Diehl; Manal F Abdelmalek Journal: Am J Gastroenterol Date: 2016-09-20 Impact factor: 10.864
Authors: Bryan Rudolph; Tyler Selig; Yingjie Li; Nadia Ovchinsky; Debora Kogan-Liberman; Mark C Liszewski; Terry Levin; Michelle Ewart; Qiang Liu; Shankar Viswanathan; Juan Lin; Xiaonan Xue; Robert D Burk; Howard D Strickler Journal: JPGN Rep Date: 2021-05