Literature DB >> 25433090

NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.

Pranay Goel1, Jantina A Manning2, Sharad Kumar3.   

Abstract

NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Epithelial sodium channel (ENaC); Hypertension; NEDD4 family; Ubiquitin; Ubiquitin protein ligases; Voltage-gated sodium channels (Na(v)s)

Mesh：

Substances：

Year:  2014        PMID： 25433090      PMCID： PMC6636357          DOI： 10.1016/j.gene.2014.11.051

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  148 in total

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Authors:  L Hicke
Journal:  Nat Rev Mol Cell Biol       Date:  2001-03       Impact factor: 94.444

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Journal:  Bioessays       Date:  1999-07       Impact factor: 4.345

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Authors:  K F Harvey; A Dinudom; D I Cook; S Kumar
Journal:  J Biol Chem       Date:  2001-01-17       Impact factor: 5.157

4.  N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

Authors:  Kieran F Harvey; Linda M Shearwin-Whyatt; Andrew Fotia; Robert G Parton; Sharad Kumar
Journal:  J Biol Chem       Date:  2001-12-17       Impact factor: 5.157

Review 5.  Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions.

Authors:  K F Harvey; S Kumar
Journal:  Trends Cell Biol       Date:  1999-05       Impact factor: 20.808

6.  NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.

Authors:  H Chen; C A Ross; N Wang; Y Huo; D F MacKinnon; J B Potash; S G Simpson; F J McMahon; J R DePaulo; M G McInnis
Journal:  Eur J Hum Genet       Date:  2001-12       Impact factor: 4.246

7.  All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.

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Journal:  J Biol Chem       Date:  1999-04-30       Impact factor: 5.157

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Authors:  Peter M Snyder; Diane R Olson; Brittany C Thomas
Journal:  J Biol Chem       Date:  2001-11-05       Impact factor: 5.157

9.  A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

Authors:  E Kamynina; C Debonneville; M Bens; A Vandewalle; O Staub
Journal:  FASEB J       Date:  2001-01       Impact factor: 5.191

10.  Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb.

Authors:  P J Plant; F Lafont; S Lecat; P Verkade; K Simons; D Rotin
Journal:  J Cell Biol       Date:  2000-06-26       Impact factor: 10.539
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  60 in total

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2.  AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.

Authors:  Pei-Yin Ho; Hui Li; Lei Cheng; Vivek Bhalla; Robert A Fenton; Kenneth R Hallows
Journal:  Am J Physiol Renal Physiol       Date:  2019-09-30

3.  Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.

Authors:  Patricio Vélez; Austin B Schwartz; Subashini R Iyer; Anthony Warrington; Debra Ann Fadool
Journal:  J Neurophysiol       Date:  2016-05-04       Impact factor: 2.714

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Journal:  Cell       Date:  2020-06-28       Impact factor: 41.582

5.  NEDD4-2-dependent control of Na+ homeostasis and renal disease.

Authors:  Jantina A Manning; Tanya L Henshall; Sharad Kumar
Journal:  Cell Cycle       Date:  2017-12-26       Impact factor: 4.534

6.  Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.

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Journal:  Hepatology       Date:  2016-05-12       Impact factor: 17.425

8.  C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms.

Authors:  Jiuhe Zhu; Kwan Young Lee; Tiffany T Jong; Nien-Pei Tsai
Journal:  J Neurochem       Date:  2019-08-25       Impact factor: 5.372

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Authors:  Natasha Anne Boase; Sharad Kumar
Journal:  Gene       Date:  2014-12-17       Impact factor: 3.688

10.  Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

Authors:  Dustin R Todaro; Allison C Augustus-Wallace; Jennifer M Klein; Arthur L Haas
Journal:  J Biol Chem       Date:  2018-10-04       Impact factor: 5.157
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