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Literature DB >> 25527121

NEDD4: The founding member of a family of ubiquitin-protein ligases.

Abstract

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the patho-physiological significance of this important ubiquitin ligase.

Entities: CellLine Chemical Disease Gene Species

Keywords: IGF signalling; NEDD4 family; PTEN; Ubiquitin; Ubiquitin protein ligases

Mesh：

Substances：

Year: 2014 PMID： 25527121 PMCID： PMC6639052 DOI： 10.1016/j.gene.2014.12.020

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

121 in total

1. The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

Authors: K F Harvey; A Dinudom; D I Cook; S Kumar
Journal: J Biol Chem Date: 2001-01-17 Impact factor: 5.157

Review 2. Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions.

Authors: K F Harvey; S Kumar
Journal: Trends Cell Biol Date: 1999-05 Impact factor: 20.808

3. A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

Authors: R N Harty; M E Brown; G Wang; J Huibregtse; F P Hayes
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

4. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

Authors: Deyu Fang; Chris Elly; Baixue Gao; Nan Fang; Yoav Altman; Claudio Joazeiro; Tony Hunter; Neal Copeland; Nancy Jenkins; Yun-Cai Liu
Journal: Nat Immunol Date: 2002-02-04 Impact factor: 25.606

5. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.

Authors: M Ikeda; A Ikeda; L C Longan; R Longnecker
Journal: Virology Date: 2000-03-01 Impact factor: 3.616

6. mGrb10 interacts with Nedd4.

Authors: A Morrione; P Plant; B Valentinis; O Staub; S Kumar; D Rotin; R Baserga
Journal: J Biol Chem Date: 1999-08-20 Impact factor: 5.157

7. Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.

Authors: A Kikonyogo; F Bouamr; M L Vana; Y Xiang; A Aiyar; C Carter; J Leis
Journal: Proc Natl Acad Sci U S A Date: 2001-09-18 Impact factor: 11.205

8. Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

Authors: E Kamynina; C Tauxe; O Staub
Journal: Am J Physiol Renal Physiol Date: 2001-09

9. Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

Authors: Menachem Katz; Keren Shtiegman; Pazit Tal-Or; Liat Yakir; Yaron Mosesson; Daniel Harari; Yossi Machluf; Hironobu Asao; Thomas Jovin; Kazuo Sugamura; Yosef Yarden
Journal: Traffic Date: 2002-10 Impact factor: 6.215

10. Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb.

Authors: P J Plant; F Lafont; S Lecat; P Verkade; K Simons; D Rotin
Journal: J Cell Biol Date: 2000-06-26 Impact factor: 10.539

46 in total

1. Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability.

Authors: Qinyu Yao; Jia Liu; Lei Xiao; Nanping Wang
Journal: J Biol Chem Date: 2018-12-20 Impact factor: 5.157

2. Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

Authors: Michael E French; Julian L Klosowiak; Aaron Aslanian; Steven I Reed; John R Yates; Tony Hunter
Journal: J Biol Chem Date: 2017-05-01 Impact factor: 5.157

3. Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.

Authors: Ilan Attali; William Sam Tobelaim; Avinash Persaud; Khatereh Motamedchaboki; Kobi J Simpson-Lavy; Bayan Mashahreh; Olga Levin-Kravets; Tal Keren-Kaplan; Inbar Pilzer; Martin Kupiec; Reuven Wiener; Dieter A Wolf; Daniela Rotin; Gali Prag
Journal: EMBO J Date: 2017-01-09 Impact factor: 11.598

4. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.

Authors: Shereen M Aleidi; Vicky Howe; Laura J Sharpe; Alryel Yang; Geetha Rao; Andrew J Brown; Ingrid C Gelissen
Journal: J Biol Chem Date: 2015-08-20 Impact factor: 5.157

5. Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.

Authors: TaeHee Kim; Anil K Chokkalla; Raghu Vemuganti
Journal: J Cereb Blood Flow Metab Date: 2020-07-23 Impact factor: 6.200

6. E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.

Authors: Qingjun Liu; Shihui Zhang; Zhongjie Sun; Xiao Guo; Hong Zhou
Journal: Cell Death Differ Date: 2019-02-28 Impact factor: 15.828

7. The C-terminal region of the yeast monocarboxylate transporter Jen1 acts as a glucose signal-responding degron recognized by the α-arrestin Rod1.

Authors: Shoki Fujita; Daichi Sato; Hirokazu Kasai; Masataka Ohashi; Shintaro Tsukue; Yutaro Takekoshi; Katsuya Gomi; Takahiro Shintani
Journal: J Biol Chem Date: 2018-05-22 Impact factor: 5.157