| Literature DB >> 25432874 |
Yao Xue1, Dongying Gu2, Gaoxiang Ma1, Lingjun Zhu3, Qiuhan Hua1, Haiyan Chu4, Na Tong4, Jinfei Chen2, Zhengdong Zhang5, Meilin Wang5.
Abstract
Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. However, the association between genetic variants in HOTAIR and cancer risk has not yet been reported. In the present study, we performed a two-stage case-control study to investigate the association between HOTAIR tagSNPs and the risk of colorectal cancer. We found that individuals with rs7958904 CC genotype had a significantly decreased risk of colorectal cancer in both Stage 1 and 2, compared with those carrying GG genotype [odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.51-0.97 in Stage 1; OR = 0.58, 95% CI = 0.37-0.91 in Stage 2; OR = 0.67, 95% CI = 0.51-0.87 in combined stage]. The subsequently stratified analyses showed that the protective effect of rs7958904 was more pronounced in several subgroups. In summary, our study showed that genetic variants in HOTAIR were associated with risk of colorectal cancer and rs7958904 may act as a potential biomarker for predicting the risk of colorectal cancer.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25432874 DOI： 10.1093/mutage/geu076
Source DB: PubMed Journal: Mutagenesis ISSN： 0267-8357 Impact factor: 3.000