Yehia El-Garem1, Mohamed El-Sawy2, Taymour Mostafa3. 1. Dermatology, Venereology & Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 2. Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 3. Department of Andrology & Sexology, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: taymour1155@link.net.
Abstract
OBJECTIVE: To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. METHODS: In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies in their seminal fluid. Infertile men with high seminal H pylori IgA were subjected to triple drug treatment, omeprazole, 20 mg; tinidazole, 500 mg; and clarithromycin, 250 mg twice a day for 2 weeks. Semen analysis as well as H pylori IgA antibodies was estimated after 3 months. RESULTS: In all, 22 of 223 men (9.87%) demonstrated H pylori IgA antibodies in their seminal plasma. After treatment, mean seminal H pylori IgA levels demonstrated significant decrease (1.55 ± 0.4 vs 0.52 ± 0.26; 95% confidence interval, 0.83-1.21; P = .001) concomitant with improved progressive as well as nonprogressive sperm motility. H pylori IgA antibodies demonstrated significant negative correlation with progressive sperm motility, nonprogressive sperm motility, normal sperm morphology, and significant positive correlation with immotile sperm motility. CONCLUSION: H pylori treatment significantly improves sperm motility in infertile asthenozoospermic men with elevated seminal H pylori IgA.
OBJECTIVE: To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. METHODS: In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies in their seminal fluid. Infertile men with high seminal H pylori IgA were subjected to triple drug treatment, omeprazole, 20 mg; tinidazole, 500 mg; and clarithromycin, 250 mg twice a day for 2 weeks. Semen analysis as well as H pylori IgA antibodies was estimated after 3 months. RESULTS: In all, 22 of 223 men (9.87%) demonstrated H pylori IgA antibodies in their seminal plasma. After treatment, mean seminal H pylori IgA levels demonstrated significant decrease (1.55 ± 0.4 vs 0.52 ± 0.26; 95% confidence interval, 0.83-1.21; P = .001) concomitant with improved progressive as well as nonprogressive sperm motility. H pylori IgA antibodies demonstrated significant negative correlation with progressive sperm motility, nonprogressive sperm motility, normal sperm morphology, and significant positive correlation with immotile sperm motility. CONCLUSION: H pylori treatment significantly improves sperm motility in infertile asthenozoospermic men with elevated seminal H pylori IgA.
Authors: Sorena Keihani; James R Craig; Chong Zhang; Angela P Presson; Jeremy B Myers; William O Brant; Kenneth I Aston; Benjamin R Emery; Timothy G Jenkins; Douglas T Carrell; James M Hotaling Journal: Asian J Androl Date: 2018 May-Jun Impact factor: 3.285