AIMS: This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. MATERIALS & METHODS: Using HumanMethylation450 arrays, we examined candidate gene-associated CpGs in cord blood from newborns with low (<15th centile), medium (40-60th centile) and high (>85th centile) BWC (n = 12). Candidates were examined in an investigation cohort (n = 110) using pyrosequencing and genotyping for putative methylation-associated polymorphisms performed using standard PCR. RESULTS: Array analysis identified 314 candidate genes associated with BWC extremes, four of which showed ≥ 4 BWC-linked CpGs. Of these, PM20D1 and MI886 suggested genetically determined methylation levels. However, methylation at three CpGs in FGFR2 remained significantly associated with high BWC (p = 0.004-0.027). CONCLUSION: We identified a novel biologically plausible candidate (FGFR2) for with BWC that merits further study.
AIMS: This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. MATERIALS & METHODS: Using HumanMethylation450 arrays, we examined candidate gene-associated CpGs in cord blood from newborns with low (<15th centile), medium (40-60th centile) and high (>85th centile) BWC (n = 12). Candidates were examined in an investigation cohort (n = 110) using pyrosequencing and genotyping for putative methylation-associated polymorphisms performed using standard PCR. RESULTS: Array analysis identified 314 candidate genes associated with BWC extremes, four of which showed ≥ 4 BWC-linked CpGs. Of these, PM20D1 and MI886 suggested genetically determined methylation levels. However, methylation at three CpGs in FGFR2 remained significantly associated with high BWC (p = 0.004-0.027). CONCLUSION: We identified a novel biologically plausible candidate (FGFR2) for with BWC that merits further study.
Authors: Peng Chen; Paolo Piaggi; Michael Traurig; Clifton Bogardus; William C Knowler; Leslie J Baier; Robert L Hanson Journal: Diabetologia Date: 2017-01-26 Impact factor: 10.122
Authors: Heather H Burris; Andrea A Baccarelli; Hyang-Min Byun; Alejandra Cantoral; Allan C Just; Ivan Pantic; Maritsa Solano-Gonzalez; Katherine Svensson; Marcela Tamayo y Ortiz; Yan Zhao; Robert O Wright; Martha M Téllez-Rojo Journal: Epigenetics Date: 2015-08-07 Impact factor: 4.528
Authors: Kiara K Benson; Wenxiang Hu; Angela H Weller; Alexis H Bennett; Eric R Chen; Sumeet A Khetarpal; Satoshi Yoshino; William P Bone; Lin Wang; Joshua D Rabinowitz; Benjamin F Voight; Raymond E Soccio Journal: Proc Natl Acad Sci U S A Date: 2019-10-28 Impact factor: 11.205
Authors: Xinyi Lin; Ives Yubin Lim; Yonghui Wu; Ai Ling Teh; Li Chen; Izzuddin M Aris; Shu E Soh; Mya Thway Tint; Julia L MacIsaac; Alexander M Morin; Fabian Yap; Kok Hian Tan; Seang Mei Saw; Michael S Kobor; Michael J Meaney; Keith M Godfrey; Yap Seng Chong; Joanna D Holbrook; Yung Seng Lee; Peter D Gluckman; Neerja Karnani Journal: BMC Med Date: 2017-03-07 Impact factor: 8.775
Authors: Anne E Justice; Tugce Karaderi; Heather M Highland; Kristin L Young; Mariaelisa Graff; Yingchang Lu; Valérie Turcot; L Adrienne Cupples; Ruth J F Loos; Kari E North; Cecilia M Lindgren; Paul L Auer; Rebecca S Fine; Xiuqing Guo; Claudia Schurmann; Adelheid Lempradl; Eirini Marouli; Anubha Mahajan; Thomas W Winkler; Adam E Locke; Carolina Medina-Gomez; Tõnu Esko; Sailaja Vedantam; Ayush Giri; Ken Sin Lo; Tamuno Alfred; Poorva Mudgal; Maggie C Y Ng; Nancy L Heard-Costa; Mary F Feitosa; Alisa K Manning; Sara M Willems; Suthesh Sivapalaratnam; Goncalo Abecasis; Dewan S Alam; Matthew Allison; Philippe Amouyel; Zorayr Arzumanyan; Beverley Balkau; Lisa Bastarache; Sven Bergmann; Lawrence F Bielak; Matthias Blüher; Michael Boehnke; Heiner Boeing; Eric Boerwinkle; Carsten A Böger; Jette Bork-Jensen; Erwin P Bottinger; Donald W Bowden; Ivan Brandslund; Linda Broer; Amber A Burt; Adam S Butterworth; Mark J Caulfield; Giancarlo Cesana; John C Chambers; Daniel I Chasman; Yii-Der Ida Chen; Rajiv Chowdhury; Cramer Christensen; Audrey Y Chu; Francis S Collins; James P Cook; Amanda J Cox; David S Crosslin; John Danesh; Paul I W de Bakker; Simon de Denus; Renée de Mutsert; George Dedoussis; Ellen W Demerath; Joe G Dennis; Josh C Denny; Emanuele Di Angelantonio; Marcus Dörr; Fotios Drenos; Marie-Pierre Dubé; Alison M Dunning; Douglas F Easton; Paul Elliott; Evangelos Evangelou; Aliki-Eleni Farmaki; Shuang Feng; Ele Ferrannini; Jean Ferrieres; Jose C Florez; Myriam Fornage; Caroline S Fox; Paul W Franks; Nele Friedrich; Wei Gan; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Giorgia Girotto; Mathias Gorski; Harald Grallert; Niels Grarup; Megan L Grove; Stefan Gustafsson; Jeff Haessler; Torben Hansen; Andrew T Hattersley; Caroline Hayward; Iris M Heid; Oddgeir L Holmen; G Kees Hovingh; Joanna M M Howson; Yao Hu; Yi-Jen Hung; Kristian Hveem; M Arfan Ikram; Erik Ingelsson; Anne U Jackson; Gail P Jarvik; Yucheng Jia; Torben Jørgensen; Pekka Jousilahti; Johanne M Justesen; Bratati Kahali; Maria Karaleftheri; Sharon L R Kardia; Fredrik Karpe; Frank Kee; Hidetoshi Kitajima; Pirjo Komulainen; Jaspal S Kooner; Peter Kovacs; Bernhard K Krämer; Kari Kuulasmaa; Johanna Kuusisto; Markku Laakso; Timo A Lakka; David Lamparter; Leslie A Lange; Claudia Langenberg; Eric B Larson; Nanette R Lee; Wen-Jane Lee; Terho Lehtimäki; Cora E Lewis; Huaixing Li; Jin Li; Ruifang Li-Gao; Li-An Lin; Xu Lin; Lars Lind; Jaana Lindström; Allan Linneberg; Ching-Ti Liu; Dajiang J Liu; Jian'an Luan; Leo-Pekka Lyytikäinen; Stuart MacGregor; Reedik Mägi; Satu Männistö; Gaëlle Marenne; Jonathan Marten; Nicholas G D Masca; Mark I McCarthy; Karina Meidtner; Evelin Mihailov; Leena Moilanen; Marie Moitry; Dennis O Mook-Kanamori; Anna Morgan; Andrew P Morris; Martina Müller-Nurasyid; Patricia B Munroe; Narisu Narisu; Christopher P Nelson; Matt Neville; Ioanna Ntalla; Jeffrey R O'Connell; Katharine R Owen; Oluf Pedersen; Gina M Peloso; Craig E Pennell; Markus Perola; James A Perry; John R B Perry; Tune H Pers; Ailith Ewing; Ozren Polasek; Olli T Raitakari; Asif Rasheed; Chelsea K Raulerson; Rainer Rauramaa; Dermot F Reilly; Alex P Reiner; Paul M Ridker; Manuel A Rivas; Neil R Robertson; Antonietta Robino; Igor Rudan; Katherine S Ruth; Danish Saleheen; Veikko Salomaa; Nilesh J Samani; Pamela J Schreiner; Matthias B Schulze; Robert A Scott; Marcelo Segura-Lepe; Xueling Sim; Andrew J Slater; Kerrin S Small; Blair H Smith; Jennifer A Smith; Lorraine Southam; Timothy D Spector; Elizabeth K Speliotes; Kari Stefansson; Valgerdur Steinthorsdottir; Kathleen E Stirrups; Konstantin Strauch; Heather M Stringham; Michael Stumvoll; Liang Sun; Praveen Surendran; Karin M A Swart; Jean-Claude Tardif; Kent D Taylor; Alexander Teumer; Deborah J Thompson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Betina H Thuesen; Anke Tönjes; Mina Torres; Emmanouil Tsafantakis; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; Cornelia M van Duijn; Mauno Vanhala; Rohit Varma; Sita H Vermeulen; Henrik Vestergaard; Veronique Vitart; Thomas F Vogt; Dragana Vuckovic; Lynne E Wagenknecht; Mark Walker; Lars Wallentin; Feijie Wang; Carol A Wang; Shuai Wang; Nicholas J Wareham; Helen R Warren; Dawn M Waterworth; Jennifer Wessel; Harvey D White; Cristen J Willer; James G Wilson; Andrew R Wood; Ying Wu; Hanieh Yaghootkar; Jie Yao; Laura M Yerges-Armstrong; Robin Young; Eleftheria Zeggini; Xiaowei Zhan; Weihua Zhang; Jing Hua Zhao; Wei Zhao; He Zheng; Wei Zhou; M Carola Zillikens; Fernando Rivadeneira; Ingrid B Borecki; J Andrew Pospisilik; Panos Deloukas; Timothy M Frayling; Guillaume Lettre; Karen L Mohlke; Jerome I Rotter; Zoltán Kutalik; Joel N Hirschhorn Journal: Nat Genet Date: 2019-02-18 Impact factor: 38.330
Authors: Valentina Chiavaroli; Wayne S Cutfield; José G B Derraik; Zengxiang Pan; Sherry Ngo; Allan Sheppard; Susan Craigie; Peter Stone; Lynn Sadler; Fredrik Ahlsson Journal: Sci Rep Date: 2015-09-30 Impact factor: 4.379