| Literature DB >> 25430075 |
Manju Bala1, Kunal Pratap, Praveen Kumar Verma, Yogendra Padwad, Bikram Singh.
Abstract
Eleven constituents were characterised by gas chromatography-mass spectrometry analysis, and five molecules were isolated using column chromatography. The in vitro study of the extract and isolated molecules against KB and SiHa cell lines revealed oleanolic acid (1) and oleic acid (2) as potent cytotoxic molecules with potential anticancer activity. The IC50 values of n-hexane extract (CPHF), oleanolic acid (1) and oleic acid (2) were >300, 56.08 and 70.7 μg/mL (μM), respectively, against KB cell lines and >300, 47.24 and 80.2 μg/mL (μM), respectively, against SiHa cell lines.Entities:
Keywords: Cissampelos pareira; anti-cancer activity; n-hexane fraction
Mesh：
Substances：
Year: 2014 PMID： 25430075 DOI： 10.1080/14786419.2014.984183
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861