Literature DB >> 25429667

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.

Jianzhuang Miao1, Huaqing Cui, Jing Jin, Fangfang Lai, Hui Wen, Xiang Zhang, Gian Filippo Ruda, Xiaoguang Chen, Dali Yin.   

Abstract

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW∼ 205.19, λab∼ 350 nm, λem∼ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25429667     DOI： 10.1039/c4cc06762b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells.

Authors:  Lichao Guo; Wen Zhang; Yanqi Xie; Xi Chen; Emma E Olmstead; Mengqiang Lian; Baochen Zhang; Yekaterina Y Zaytseva; B Mark Evers; H Peter Spielmann; Xifu Liu; David S Watt; Chunming Liu
Journal:  Mol Cancer Ther       Date:  2022-05-04       Impact factor: 6.009

Review 2.  Photoredox-Mediated Routes to Radicals: The Value of Catalytic Radical Generation in Synthetic Methods Development.

Authors:  Jennifer K Matsui; Simon B Lang; Drew R Heitz; Gary A Molander
Journal:  ACS Catal       Date:  2017-03-14       Impact factor: 13.084

3.  Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds.

Authors:  Chunxian He; Laura Preiss; Bin Wang; Lei Fu; Hui Wen; Xiang Zhang; Huaqing Cui; Thomas Meier; Dali Yin
Journal:  ChemMedChem       Date:  2016-10-28       Impact factor: 3.466

4.  Direct α-Arylation/Heteroarylation of 2-Trifluoroboratochromanones via Photoredox/Nickel Dual Catalysis.

Authors:  Jennifer K Matsui; Gary A Molander
Journal:  Org Lett       Date:  2017-01-12       Impact factor: 6.005

5.  Beyond the Antagonism: Self-Labeled Xanthone Inhibitors as Modeled "Two-in-One" Drugs in Cancer Therapy.

Authors:  Fu-Chao Yu; Xin-Rong Lin; Zhi-Cheng Liu; Ji-Hong Zhang; Fei-Fei Liu; Wei Wu; Yu-Lu Ma; Wen-Wen Qu; Sheng-Jiao Yan; Jun Lin
Journal:  ACS Omega       Date:  2017-03-13

6.  A Mild Aqueous Sonogashira Reaction as a Fluorescent Labeling Strategy for 5-Bromide-2'-Deoxyuridine.

Authors:  Shufang Wang; Yongxin Gao; Shigang Shen; Hui Wen; Huaqing Cui
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

7.  Insights Into the Detection Selectivity of Redox and Non-redox Based Probes for the Superoxide Anion Using Coumarin and Chromone as the Fluorophores.

Authors:  Yuchen Wang; Shumi Jia; Zhenyan Yu; Hui Wen; Huaqing Cui
Journal:  Front Chem       Date:  2021-11-25       Impact factor: 5.221

8.  Exploration of the Fluorescent Properties and the Modulated Activities against Sirtuin Fluorogenic Assays of Chromenone-Derived Natural Products.

Authors:  Hui Wen; Nina Xue; Feng Wu; Yujun He; Gang Zhang; Zebin Hu; Huaqing Cui
Journal:  Molecules       Date:  2018-05-02       Impact factor: 4.411

9.  Quantitative Evaluation of in Vivo Target Efficacy of Anti-tumor Agents via an Immunofluorescence and EdU Labeling Strategy.

Authors:  Yujun He; Jin Wen; Qinghua Cui; Fangfang Lai; Dali Yin; Huaqing Cui
Journal:  Front Pharmacol       Date:  2018-07-25       Impact factor: 5.810
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.