Mario Vaccaro1, Serafinella P Cannavò1, Selene Imbesi2, Mariateresa Cristani3, Olga Barbuzza2, Valeria Tigano2, Sebastiano Gangemi2,4. 1. Institute of Dermatology, University of Messina, Messina, Italy. 2. Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University of Messina, Messina, Italy. 3. Department Farmaco-Biologico, School of Pharmacy, University of Messina, Messina, Italy. 4. Institute of Biomedicine and Molecular Immunology "A. Monroy" (IBIM), Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy.
Abstract
INTRODUCTION: Vitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology. METHODS: In order to sustain the role of T-helper-17 lymphocytes in the pathogenesis of vitiligo, we measured the serum levels of interleukin (IL)-23 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58 years) affected by non-segmental vitiligo and compared the results with a group of healthy donors. RESULTS: IL-23 serum levels were significantly higher in patients with vitiligo as compared with controls. There was a significant positive correlation of IL-23 serum levels with disease duration and extent of vitiligo and disease activity. CONCLUSIONS: The inhibition of IL-23 might be a novel strategy in the therapy of autoimmune inflammatory diseases like vitiligo.
INTRODUCTION: Vitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology. METHODS: In order to sustain the role of T-helper-17 lymphocytes in the pathogenesis of vitiligo, we measured the serum levels of interleukin (IL)-23 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58 years) affected by non-segmental vitiligo and compared the results with a group of healthy donors. RESULTS:IL-23 serum levels were significantly higher in patients with vitiligo as compared with controls. There was a significant positive correlation of IL-23 serum levels with disease duration and extent of vitiligo and disease activity. CONCLUSIONS: The inhibition of IL-23 might be a novel strategy in the therapy of autoimmune inflammatory diseases like vitiligo.
Authors: Mario Vaccaro; Natasha Irrera; Giuseppina Cutroneo; Giuseppina Rizzo; Federico Vaccaro; Giuseppe P Anastasi; Francesco Borgia; Serafinella P Cannavò; Domenica Altavilla; Francesco Squadrito Journal: Int J Mol Sci Date: 2017-11-26 Impact factor: 5.923
Authors: Paolo Custurone; Luca Di Bartolomeo; Natasha Irrera; Francesco Borgia; Domenica Altavilla; Alessandra Bitto; Giovanni Pallio; Francesco Squadrito; Mario Vaccaro Journal: Int J Mol Sci Date: 2021-10-22 Impact factor: 5.923
Authors: Luca Di Bartolomeo; Domenica Altavilla; Mario Vaccaro; Federico Vaccaro; Violetta Squadrito; Francesco Squadrito; Francesco Borgia Journal: Front Pharmacol Date: 2022-08-16 Impact factor: 5.988