Literature DB >> 2542598

Aphidicolin resistance in herpes simplex virus type 1 appears to alter substrate specificity in the DNA polymerase.

J D Hall1, S Woodward.   

Abstract

We describe novel mutants of herpes simplex virus which are resistant to aphidicolin. Their mutant phenotypes suggest that they encode DNA polymerases with altered substrate recognition. This conclusion is based on their abnormal sensitivity to polymerase inhibitors and to the abnormal mutation rates exhibited by two of the mutants.

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Year:  1989        PMID： 2542598      PMCID： PMC250806     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

Authors:  J S Gibbs; H C Chiou; K F Bastow; Y C Cheng; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

Review 2.  Modeling functional sites in DNA polymerases.

Authors:  J D Hall
Journal:  Trends Genet       Date:  1988-02       Impact factor: 11.639

3.  The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase alpha.

Authors:  M Oguro; C Suzuki-Hori; H Nagano; Y Mano; S Ikegami
Journal:  Eur J Biochem       Date:  1979-07

4.  Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation.

Authors:  D Derse; Y C Cheng
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157

5.  Inhibition of herpes simplex virus-induced DNA polymerase, cellular DNA polymerase alpha, and virus production by aphidicolin.

Authors:  R A Dicioccio; K Chadha; B I Sahai Srivastava
Journal:  Biochim Biophys Acta       Date:  1980-09-19

6.  New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.

Authors:  J A Huberman
Journal:  Cell       Date:  1981-03       Impact factor: 41.582

7.  Inhibition of DNA synthesis in the adenovirus DNA replication complex by aphidicolin and 2',3'-dideoxythymidine triphosphate.

Authors:  A Habara; K Kano; H Nagano; Y Mano; S Ikegami; T Yamashita
Journal:  Biochem Biophys Res Commun       Date:  1980-01-15       Impact factor: 3.575

8.  The effect of aphidicolin on adenovirus DNA synthesis.

Authors:  M Longiaru; J E Ikeda; Z Jarkovsky; S B Horwitz; M S Horwitz
Journal:  Nucleic Acids Res       Date:  1979-07-25       Impact factor: 16.971

9.  The effect of aphidicolin on DNA synthesis in isolated HeLa cell nuclei.

Authors:  E Wist; H Prydz
Journal:  Nucleic Acids Res       Date:  1979-04       Impact factor: 16.971

Review 10.  Aranucleosides and aranucleotides in viral chemotherapy.

Authors:  T W North; S S Cohen
Journal:  Pharmacol Ther       Date:  1979       Impact factor: 12.310
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  7 in total

1.  Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.

Authors:  Egor P Tchesnokov; Christian Gilbert; Guy Boivin; Matthias Götte
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

2.  Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.

Authors:  Robert A Smith; Donovan J Anderson; Bradley D Preston
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

3.  Aphidicolin resistance in herpes simplex virus type I reveals features of the DNA polymerase dNTP binding site.

Authors:  J D Hall; Y S Wang; J Pierpont; M S Berlin; S E Rundlett; S Woodward
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971

4.  Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutations.

Authors:  Guozhong Feng; David K Thumbi; Jondavid de Jong; Jeffrey J Hodgson; Basil M Arif; Daniel Doucet; Peter J Krell
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

5.  Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity.

Authors:  J A Taddie; P Traktman
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

6.  Modified FGF4 signal peptide inhibits entry of herpes simplex virus type 1.

Authors:  H Bultmann; J S Busse; C R Brandt
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

7.  Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner.

Authors:  Kai A Kropp; Alberto Domingo López-Muñoz; Birgit Ritter; Rocío Martín; Alberto Rastrojo; Sangar Srivaratharajan; Katinka Döhner; Akshay Dhingra; Julia S Czechowicz; Claus-Henning Nagel; Beate Sodeik; Antonio Alcami; Abel Viejo-Borbolla
Journal:  J Virol       Date:  2020-09-29       Impact factor: 5.103
  7 in total

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