| Literature DB >> 2542555 |
N M Gray1, B K Cheng, S J Mick, C M Lair, P C Contreras.
Abstract
A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno[2,3-c]pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-1-[1-(2-thienyl)piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and sigma receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.Entities:
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Year: 1989 PMID： 2542555 DOI： 10.1021/jm00126a016
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446