Literature DB >> 7394531

Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex.

J N Nestoros.   

Abstract

Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by gamma-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibiton by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) gamma-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.

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Year:  1980        PMID： 7394531     DOI： 10.1126/science.7394531

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  46 in total

1.  Cerebellar GABAA receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity.

Authors:  M Uusi-Oukari; E R Korpi
Journal:  Neurochem Res       Date:  1989-08       Impact factor: 3.996

2.  Update on the neurobiology of alcohol withdrawal seizures.

Authors:  Michael A Rogawski
Journal:  Epilepsy Curr       Date:  2005 Nov-Dec       Impact factor: 7.500

3.  Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats.

Authors:  Khemraj Hirani; Ajay N Sharma; Nishant S Jain; Rajesh R Ugale; Chandrabhan T Chopde
Journal:  Psychopharmacology (Berl)       Date:  2005-02-18       Impact factor: 4.530

4.  Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors.

Authors:  Dipak V Amrutkar; Tino Dyhring; Thomas A Jacobsen; Janus S Larsen; Karin Sandager-Nielsen
Journal:  Cerebellum       Date:  2020-04       Impact factor: 3.847

Review 5.  GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons.

Authors:  M R Palmer; B J Hoffer
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

6.  Contributions of hippocampus and neocortex to the expression of ethanol effects.

Authors:  L D Devenport; R L Hale
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

Authors:  P D Suzdak; R D Schwartz; P Skolnick; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

Review 8.  Seizures in alcohol-dependent patients: epidemiology, pathophysiology and management.

Authors:  Matti Hillbom; Ilkka Pieninkeroinen; Maurizio Leone
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

9.  Changes in intrinsic inhibition in isolated hippocampal slices during ethanol withdrawal; lack of correlation with withdrawal hyperexcitability.

Authors:  M A Whittington; H J Little; J D Lambert
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

Review 10.  Translational studies of alcoholism: bridging the gap.

Authors:  Natalie M Zahr; Edith V Sullivan
Journal:  Alcohol Res Health       Date:  2008
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