Meihui Shan1, Xiaoli Wang1, Gang Sun1, Binlin Ma1, Xuemei Yao2, Alibiyati Ainy1, Jing Ma1, Chao Dong1, Hongtao Li1, Muzapar Abudukeremu1. 1. Department of Breast and Neck, The Affiliated Tumor Hospital of Xinjiang Medical University 789 East Suzhou Street, Urumqi 830011, Xinjiang, China. 2. Department of Epidemiology and Health Statistics, Public Health College of Xinjiang Medical University 8 Medical University Road, Urumqi 830054, Xinjiang, China.
Abstract
BACKGROUND: Studies support biological disparities of breast cancer among races/ethnicities. Uygur is a minority ethnic group in China with a genetic admixture of Caucasian and East Asian. The Han ethnic group makes up the majority of the Chinese population. We aim to study and compare the clinical differences and survival rate in these two ethnic groups in order to improve prophylaxis. METHODS: A retrospective analysis of the medical records of 264 Uygur and 287 Han breast cancer patients including demographic data, clinical and pathological parameters, TNM status, Ki-67 and treatment information was collected. The patients were followed up at three month intervals for 2 years then every 6 months for 3 to 4 years postoperatively. Chi-square tests were performed to compare characteristics, and a log-rank test was used for ranked data. Overall survival and disease free survival were analyzed by Kaplan Meier tests. RESULTS: Uygur was statistically different in terms of: marital status; occupation; body mass index; duration of breast feeding; period of complaint; pathological composition; size of primary tumor; number of metastatic and resected lymph nodes; pathological staging; expression of nm23; chemotherapy and radiotherapy. The 5-year overall survival rate of Uygur breast cancer patients was 89.2% compared to 91.7% in Han (P = 0.129). The disease free survival of Uygur breast cancer patients was 79.3% compared to 84.5% in Han (P = 0.040). CONCLUSION: The different characteristics of Uygur breast cancer patients compared to Han breast cancer patients and their lower survival rates indicate that management strategies should be implemented to improve patient outcome.
BACKGROUND: Studies support biological disparities of breast cancer among races/ethnicities. Uygur is a minority ethnic group in China with a genetic admixture of Caucasian and East Asian. The Han ethnic group makes up the majority of the Chinese population. We aim to study and compare the clinical differences and survival rate in these two ethnic groups in order to improve prophylaxis. METHODS: A retrospective analysis of the medical records of 264 Uygur and 287 Han breast cancerpatients including demographic data, clinical and pathological parameters, TNM status, Ki-67 and treatment information was collected. The patients were followed up at three month intervals for 2 years then every 6 months for 3 to 4 years postoperatively. Chi-square tests were performed to compare characteristics, and a log-rank test was used for ranked data. Overall survival and disease free survival were analyzed by Kaplan Meier tests. RESULTS: Uygur was statistically different in terms of: marital status; occupation; body mass index; duration of breast feeding; period of complaint; pathological composition; size of primary tumor; number of metastatic and resected lymph nodes; pathological staging; expression of nm23; chemotherapy and radiotherapy. The 5-year overall survival rate of Uygur breast cancerpatients was 89.2% compared to 91.7% in Han (P = 0.129). The disease free survival of Uygur breast cancerpatients was 79.3% compared to 84.5% in Han (P = 0.040). CONCLUSION: The different characteristics of Uygur breast cancerpatients compared to Han breast cancerpatients and their lower survival rates indicate that management strategies should be implemented to improve patient outcome.
Entities:
Keywords:
Breast neoplasms; China; ethnic groups; population characteristics; survival
Authors: Bent Ejlertsen; Henning T Mouridsen; Maj-Britt Jensen; Jørn Andersen; Søren Cold; Per Edlund; Marianne Ewertz; Brita B Jensen; Claus Kamby; Bo Nordenskjold; Jonas Bergh Journal: Eur J Cancer Date: 2007-02-16 Impact factor: 9.162
Authors: Yadong Cui; Maura K Whiteman; Patricia Langenberg; Mary Sexton; Katherine H Tkaczuk; Jodi A Flaws; Trudy L Bush Journal: J Womens Health Gend Based Med Date: 2002 Jul-Aug