Yipeng Song1, Yuanna Du1, Qi Zhou2, Jinbo Ma1, Jinming Yu3, Xiaofeng Tao4, Fenghua Zhang5. 1. Department of Radiation Oncology, Affiliated Yantai Yuhuangding Hospital, Qingdao University Yantai 264000, China. 2. Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University Changzhou 213003, Jiangsu Province, China. 3. Department of Radiation Oncology, Shandong Cancer Hospital Jinan 250012, Shandong, China. 4. Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200011, China. 5. Department of General Surgery, Hebei General Hospital Shijiazhuang 050051, Hebei, China.
Abstract
BACKGROUND: The association of glutathione s-transferase P1 (GSTP1) Ile105Val polymorphism with risk of esophageal cancer (EC) has been evaluated in many studies; however, the results from these studies are controversial. Thus, further analysis on association between GSTP1 Ile105Val polymorphism and risk of EC is needed among a larger study population. METHOD: We searched the relevant electronic databases and performed a meta-analysis based on 21 published case-control studies. The Chi-square based I(2)-statistic test was performed to evaluate possible heterogeneity across the studies. Additionally, random-effects models were used to calculate crude pooled odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Overall, this meta-analysis did support a significant association between GSTP1 Ile105Val polymorphism and risk of EC (pooled OR 1.25, 95% CI, 1.05-1.49). Furthermore, the stratified analysis showed that, in comparison to GSTP1 Ile105Val Ile/Ile genotype, the Val/Val genotype was significantly associated with risk of esophageal squamous cell carcinoma (ESCC) (pooled OR 1.45, 95% CI, 1.07-1.96), particularly in the Caucasian population (pooled OR 1.41, 95% CI, 1.01-1.95). Such a significant association was not observed for esophageal adenocarcinoma (EAC) patients or subjects of an Asian ethnicity. Moreover, substantial evidence of heterogeneity among the studies was not observed. CONCLUSION: The results from this meta-analysis support a significant association between the GSTP1 Ile105Val polymorphism and risk of EC, particularly in a subgroup with ESCC and in the Caucasian population. Further studies with larger sample sizes are needed to validate our findings.
BACKGROUND: The association of glutathione s-transferase P1 (GSTP1) Ile105Val polymorphism with risk of esophageal cancer (EC) has been evaluated in many studies; however, the results from these studies are controversial. Thus, further analysis on association between GSTP1Ile105Val polymorphism and risk of EC is needed among a larger study population. METHOD: We searched the relevant electronic databases and performed a meta-analysis based on 21 published case-control studies. The Chi-square based I(2)-statistic test was performed to evaluate possible heterogeneity across the studies. Additionally, random-effects models were used to calculate crude pooled odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Overall, this meta-analysis did support a significant association between GSTP1Ile105Val polymorphism and risk of EC (pooled OR 1.25, 95% CI, 1.05-1.49). Furthermore, the stratified analysis showed that, in comparison to GSTP1Ile105Val Ile/Ile genotype, the Val/Val genotype was significantly associated with risk of esophageal squamous cell carcinoma (ESCC) (pooled OR 1.45, 95% CI, 1.07-1.96), particularly in the Caucasian population (pooled OR 1.41, 95% CI, 1.01-1.95). Such a significant association was not observed for esophageal adenocarcinoma (EAC) patients or subjects of an Asian ethnicity. Moreover, substantial evidence of heterogeneity among the studies was not observed. CONCLUSION: The results from this meta-analysis support a significant association between the GSTP1Ile105Val polymorphism and risk of EC, particularly in a subgroup with ESCC and in the Caucasian population. Further studies with larger sample sizes are needed to validate our findings.
Entities:
Keywords:
Esophageal cancer; GSTP1; cancer risk; meta-analysis; polymorphism
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