Literature DB >> 25418613

Active site targeting of hedgehog precursor protein with phenylarsine oxide.

Timothy S Owen1, Xie Jian Xie, Benjamin Laraway, George Ngoje, Chunyu Wang, Brian P Callahan.   

Abstract

Hedgehog proteins, signaling molecules implicated in human embryo development and cancer, can be inhibited at the stage of autoprocessing by the trivalent arsenical phenyl arsine oxide (PhAs(III) ). The interaction (apparent Ki , 4 × 10(-7) M) is characterized by an optical binding assay and by NMR spectroscopy. PhAs(III) appears to be the first validated inhibitor of hedgehog autoprocessing, which is unique to hedgehog proteins and essential for biological activity.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  active-site probe; arsenic; autoprocessing; cholesterol; hedgehog

Mesh：

Substances：

Year:  2014        PMID： 25418613      PMCID： PMC4430098          DOI： 10.1002/cbic.201402421

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  21 in total

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Authors:  Randall K Mann; Philip A Beachy
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

2.  A high-throughput, homogeneous, fluorescence polarization assay for inhibitors of hedgehog protein autoprocessing.

Authors:  Shu-qin Jiang; Henry Paulus
Journal:  J Biomol Screen       Date:  2010-10

3.  Modulation of intein activity by its neighboring extein substrates.

Authors:  Gil Amitai; Brian P Callahan; Matt J Stanger; Georges Belfort; Marlene Belfort
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-17       Impact factor: 11.205

4.  Bioorthogonal chemical tagging of protein cholesterylation in living cells.

Authors:  William P Heal; Biljana Jovanovic; Sara Bessin; Megan H Wright; Anthony I Magee; Edward W Tate
Journal:  Chem Commun (Camb)       Date:  2011-01-11       Impact factor: 6.222

5.  Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.

Authors:  Jynho Kim; John J Lee; James Kim; Dale Gardner; Philip A Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 6.  The Hedgehog's tale: developing strategies for targeting cancer.

Authors:  Jessica M Y Ng; Tom Curran
Journal:  Nat Rev Cancer       Date:  2011-05-26       Impact factor: 60.716

7.  A specific and sensitive assay for disulfides.

Authors:  W L Zahler; W W Cleland
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8.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.

Authors:  C Chiang; Y Litingtung; E Lee; K E Young; J L Corden; H Westphal; P A Beachy
Journal:  Nature       Date:  1996-10-03       Impact factor: 49.962

9.  Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing.

Authors:  Marie Paule Strub; François Hoh; Jean Frédéric Sanchez; Jean Marc Strub; August Böck; André Aumelas; Christian Dumas
Journal:  Structure       Date:  2003-11       Impact factor: 5.006

10.  Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.

Authors:  Xin Chen; Hanna Tukachinsky; Chih-Hsiang Huang; Cindy Jao; Yue-Ru Chu; Hsiang-Yun Tang; Britta Mueller; Sol Schulman; Tom A Rapoport; Adrian Salic
Journal:  J Cell Biol       Date:  2011-02-28       Impact factor: 10.539
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  9 in total

1.  Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer.

Authors:  Brandon M Bordeau; Daniel A Ciulla; Brian P Callahan
Journal:  ChemMedChem       Date:  2016-07-20       Impact factor: 3.466

2.  Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activation.

Authors:  Jian Xie; Timothy Owen; Ke Xia; Ajay Vikram Singh; Emiley Tou; Lingyun Li; Brigitte Arduini; Hongmin Li; Leo Q Wan; Brian Callahan; Chunyu Wang
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

3.  Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction.

Authors:  Andrew E Owens; Ivan de Paola; William A Hansen; Yi-Wen Liu; Sagar D Khare; Rudi Fasan
Journal:  J Am Chem Soc       Date:  2017-08-30       Impact factor: 15.419

4.  Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.

Authors:  Carl J Smith; Andrew G Wagner; Robert T Stagnitta; Zihan Xu; John L Pezzullo; José-Luis Giner; Jian Xie; Douglas F Covey; Chunyu Wang; Brian P Callahan
Journal:  Biochemistry       Date:  2020-02-04       Impact factor: 3.162

5.  Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.

Authors:  Timothy S Owen; George Ngoje; Travis J Lageman; Brandon M Bordeau; Marlene Belfort; Brian P Callahan
Journal:  Anal Biochem       Date:  2015-06-18       Impact factor: 3.365

Review 6.  Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery.

Authors:  Nabin Kandel; Chunyu Wang
Journal:  Front Mol Biosci       Date:  2022-05-20

7.  A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing.

Authors:  Jian Xie; Timothy Owen; Ke Xia; Brian Callahan; Chunyu Wang
Journal:  J Am Chem Soc       Date:  2016-08-19       Impact factor: 15.419

8.  Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition.

Authors:  Andrew G Wagner; Robert T Stagnitta; Zihan Xu; John L Pezzullo; Nabin Kandel; José-Luis Giner; Douglas F Covey; Chunyu Wang; Brian P Callahan
Journal:  Biochemistry       Date:  2021-12-23       Impact factor: 3.321

Review 9.  Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling.

Authors:  Brian P Callahan; Chunyu Wang
Journal:  Cancers (Basel)       Date:  2015-10-14       Impact factor: 6.639
  9 in total

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