Literature DB >> 25416858

Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome.

Narayan Ramakrishna1, Harry C Meeker2, W Ted Brown3.   

Abstract

Alpha-synuclein (SNCA), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.

Entities:  

Keywords:  Alpha-synuclein; Demethylation; Down syndrome; EGCG; Ts65Dn mice

Mesh：

Substances：

Year:  2014        PMID： 25416858     DOI： 10.1007/s12035-014-8979-z

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  22 in total

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Review 3.  DNA methylation and human disease.

Authors:  Keith D Robertson
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5.  Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice.

Authors:  Narayan Ramakrishna; Clifford Meeker; Shuyun Li; Edmund C Jenkins; Julia R Currie; Michael Flory; Beena Lee; Ming S Liu; David L Miller
Journal:  Anal Biochem       Date:  2005-05-15       Impact factor: 3.365

6.  CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.

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7.  Global disruption of the cerebellar transcriptome in a Down syndrome mouse model.

Authors:  Nidhi G Saran; Mathew T Pletcher; JoAnne E Natale; Ying Cheng; Roger H Reeves
Journal:  Hum Mol Genet       Date:  2003-08-15       Impact factor: 6.150

8.  Domains of genome-wide gene expression dysregulation in Down's syndrome.

Authors:  Audrey Letourneau; Federico A Santoni; Ximena Bonilla; M Reza Sailani; David Gonzalez; Jop Kind; Claire Chevalier; Robert Thurman; Richard S Sandstrom; Youssef Hibaoui; Marco Garieri; Konstantin Popadin; Emilie Falconnet; Maryline Gagnebin; Corinne Gehrig; Anne Vannier; Michel Guipponi; Laurent Farinelli; Daniel Robyr; Eugenia Migliavacca; Christelle Borel; Samuel Deutsch; Anis Feki; John A Stamatoyannopoulos; Yann Herault; Bas van Steensel; Roderic Guigo; Stylianos E Antonarakis
Journal:  Nature       Date:  2014-04-17       Impact factor: 49.962

9.  DNA methylation in cognition comes of age.

Authors:  Susan C Su; Li-Huei Tsai
Journal:  Nat Neurosci       Date:  2012-07-26       Impact factor: 24.884

10.  MeCP2, a key contributor to neurological disease, activates and represses transcription.

Authors:  Maria Chahrour; Sung Yun Jung; Chad Shaw; Xiaobo Zhou; Stephen T C Wong; Jun Qin; Huda Y Zoghbi
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