| Literature DB >> 2541219 |
A Wright1, J E Lee, M P Link, S D Smith, W Carroll, R Levy, C Clayberger, A M Krensky.
Abstract
CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.Entities:
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Year: 1989 PMID: 2541219 PMCID: PMC2189325 DOI: 10.1084/jem.169.5.1557
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307