| Literature DB >> 2540757 |
T Ishikawa1, Y Fujiyama, O Igarashi, M Morino, N Tada, A Kagami, T Sakamoto, M Nagano, H Nakamura.
Abstract
Nineteen hypercholesterolemic patients (10 without and 9 with hypertriglyceridemia) were given evening primrose oil rich in gammalinolenic acid (GLA, 18: 3n - 6), in a placebo controlled cross-over design, over 16 weeks (8 + 8 weeks), with safflower oil as the placebo. During supplementation with evening primrose oil, dihomogammalinolenic acid (20: 3n - 6) increased in plasma lipids and red blood cells, and in subjects without hypertriglyceridemia there was a significant decrease in low density lipoprotein-cholesterol and plasma apolipoprotein B compared with the levels observed during safflower oil administration. Our results confirmed that evening primrose oil is effective in lowering low density lipoprotein in hypercholesterolemic patients.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2540757 DOI： 10.1016/0021-9150(89)90165-2
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162