BACKGROUND: Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. METHODS: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. RESULTS: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20% per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. CONCLUSIONS: NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.
BACKGROUND:Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. METHODS: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. RESULTS: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20% per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. CONCLUSIONS:NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.
Authors: Philip D Sloane; Christopher H Schifeling; Anna S Beeber; Kimberly T Ward; David Reed; Lisa P Gwyther; Bobbi Matchar; Sheryl Zimmerman Journal: J Am Geriatr Soc Date: 2017-02-02 Impact factor: 5.562
Authors: Jeannie-Marie S Leoutsakos; Elizabeth A Wise; Constantine G Lyketsos; Gwenn S Smith Journal: Int J Geriatr Psychiatry Date: 2019-09-02 Impact factor: 3.485
Authors: John J McGrath; Sukanta Saha; Ali O Al-Hamzawi; Jordi Alonso; Laura Andrade; Guilherme Borges; Evelyn J Bromet; Mark Oakley Browne; Ronny Bruffaerts; Jose M Caldas de Almeida; John Fayyad; Silvia Florescu; Giovanni de Girolamo; Oye Gureje; Chiyi Hu; Peter de Jonge; Viviane Kovess-Masfety; Jean Pierre Lepine; Carmen C W Lim; Fernando Navarro-Mateu; Maria Piazza; Nancy Sampson; José Posada-Villa; Kenneth S Kendler; Ronald C Kessler Journal: Schizophr Bull Date: 2016-04-02 Impact factor: 9.306
Authors: Gill Livingston; Julie Barber; Louise Marston; Penny Rapaport; Deborah Livingston; Sian Cousins; Sarah Robertson; Francesca La Frenais; Claudia Cooper Journal: BJPsych Open Date: 2017-07-27
Authors: Kun Hu; Rixt F Riemersma-van der Lek; Melissa Patxot; Peng Li; Steven A Shea; Frank A J L Scheer; Eus J W Van Someren Journal: Sci Rep Date: 2016-06-13 Impact factor: 4.379