Literature DB >> 25403260

Efficient Cu(OTf)2-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1H)-ones.

Xiaoyan Zhu1, So Rang Kang, Likai Xia, Jihye Lee, Nagaraj Basavegowda, Yong Rok Lee.   

Abstract

An efficient one-pot synthesis of various 2,3-dihydroquinazolin-4(1H)-one derivatives was accomplished using Cu(OTf)2-catalyzed multi-component reactions between isatoic anhydride, ketones, and amines. The method has several significant advantages; mild reaction conditions, easy handling, and efficiency of catalyst.

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Year:  2014        PMID： 25403260     DOI： 10.1007/s11030-014-9557-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  11 in total

1.  Design, synthesis and antiviral activity of novel quinazolinones.

Authors:  Ziwen Wang; Mingxiao Wang; Xue Yao; Yue Li; Juan Tan; Lizhong Wang; Wentao Qiao; Yunqi Geng; Yuxiu Liu; Qingmin Wang
Journal:  Eur J Med Chem       Date:  2012-04-19       Impact factor: 6.514

2.  Facile method for the combinatorial synthesis of 2,2-disubstituted quinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids.

Authors:  Xiang-Shan Wang; Ke Yang; Jie Zhou; Shu-Jiang Tu
Journal:  J Comb Chem       Date:  2010-07-12

3.  Asymmetric Brønsted acid catalysis: catalytic enantioselective synthesis of highly biologically active dihydroquinazolinones.

Authors:  Magnus Rueping; Andrey P Antonchick; Erli Sugiono; Konstantin Grenader
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

4.  One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines.

Authors:  Kathryn G Guggenheim; Hannah Toru; Mark J Kurth
Journal:  Org Lett       Date:  2012-06-29       Impact factor: 6.005

5.  Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists.

Authors:  Mohamed A H Ismail; Stewart Barker; Dalal A Abou el-Ella; Khaled A M Abouzid; Rabab A Toubar; Matthew H Todd
Journal:  J Med Chem       Date:  2006-03-09       Impact factor: 7.446

6.  New quinazolinone-pyrimidine hybrids: synthesis, anti-inflammatory, and ulcerogenicity studies.

Authors:  Safinaz E Abbas; Fadi M Awadallah; Nashwa A Ibrahin; Eman G Said; Gihan M Kamel
Journal:  Eur J Med Chem       Date:  2012-04-09       Impact factor: 6.514

Review 7.  Quinoline, quinazoline and acridone alkaloids.

Authors:  Joseph P Michael
Journal:  Nat Prod Rep       Date:  2004-09-14       Impact factor: 13.423

8.  Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species.

Authors:  I A Rivero; K Espinoza; R Somanathan
Journal:  Molecules       Date:  2004-06-30       Impact factor: 4.411

9.  Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.

Authors:  Gary M Chinigo; Mikell Paige; Scott Grindrod; Ernest Hamel; Sivanesan Dakshanamurthy; Maksymilian Chruszcz; Wladek Minor; Milton L Brown
Journal:  J Med Chem       Date:  2008-07-09       Impact factor: 7.446

10.  Direct catalytic asymmetric synthesis of cyclic aminals from aldehydes.

Authors:  Xu Cheng; Sreekumar Vellalath; Richard Goddard; Benjamin List
Journal:  J Am Chem Soc       Date:  2008-11-26       Impact factor: 15.419
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  1 in total

Review 1.  2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design.

Authors:  Mariateresa Badolato; Francesca Aiello; Nouri Neamati
Journal:  RSC Adv       Date:  2018-06-07       Impact factor: 4.036
  1 in total

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