Literature DB >> 2540286

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

G Lennox1, J Lowe, K Morrell, M Landon, R J Mayer.   

Abstract

Brainstem and cortical Lewy bodies in diffuse Lewy body disease show intense immunoreactivity to antibodies against ubiquitin. Quantitative studies show that the novel neuropathological technique of anti-ubiquitin immunocytochemistry is more than twice as sensitive as conventional haematoxylin and eosin stains in detecting cortical Lewy bodies. Anti-ubiquitin immunocytochemistry should be regarded as the method of choice for the diagnosis and quantification of diffuse Lewy body disease.

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Year:  1989        PMID： 2540286      PMCID： PMC1032659          DOI： 10.1136/jnnp.52.1.67

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  10 in total

1.  Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments.

Authors:  L S Forno; L A Sternberger; N H Sternberger; A M Strefling; K Swanson; L F Eng
Journal:  Neurosci Lett       Date:  1986-03-14       Impact factor: 3.046

2.  The Lewy body in Parkinson's disease.

Authors:  L S Forno
Journal:  Adv Neurol       Date:  1987

3.  Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.

Authors:  S Kuzuhara; H Mori; N Izumiyama; M Yoshimura; Y Ihara
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

Review 4.  Ubiquitin-mediated pathways for intracellular proteolysis.

Authors:  M Rechsteiner
Journal:  Annu Rev Cell Biol       Date:  1987

5.  Analysis of cerebellar motor disorders by visually-guided elbow tracking movement. 2. Contribution of the visual cues on slow ramp pursuit.

Authors:  H Beppu; M Nagaoka; R Tanaka
Journal:  Brain       Date:  1987-02       Impact factor: 13.501

6.  Dementia and Parkinson's disease associated with diffuse cortical Lewy bodies.

Authors:  E J Byrne; J Lowe; R B Godwin-Austen; T Arie; R Jones
Journal:  Lancet       Date:  1987-02-28       Impact factor: 79.321

7.  Lewy bodies of Parkinson's disease contain neurofilament antigens.

Authors:  J E Goldman; S H Yen; F C Chiu; N S Peress
Journal:  Science       Date:  1983-09-09       Impact factor: 47.728

8.  Lewy bodies in cerebral cortex, report of three cases.

Authors:  K Kosaka
Journal:  Acta Neuropathol       Date:  1978-05-24       Impact factor: 17.088

9.  Diffuse Lewy body disease. Neuropathological and biochemical studies of six patients.

Authors:  D W Dickson; P Davies; R Mayeux; H Crystal; D S Horoupian; A Thompson; J E Goldman
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

10.  Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease.

Authors:  J Lowe; A Blanchard; K Morrell; G Lennox; L Reynolds; M Billett; M Landon; R J Mayer
Journal:  J Pathol       Date:  1988-05       Impact factor: 7.996
  10 in total
  33 in total

1.  Relationships between Lewy bodies and pale bodies in Parkinson's disease.

Authors:  G E Dale; A Probst; P Luthert; J Martin; B H Anderton; P N Leigh
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

Review 2.  Protein degradation pathways in Parkinson's disease: curse or blessing.

Authors:  Darius Ebrahimi-Fakhari; Lara Wahlster; Pamela J McLean
Journal:  Acta Neuropathol       Date:  2012-06-29       Impact factor: 17.088

3.  An adult-onset case of sporadic motor neuron disease with basophilic inclusions.

Authors:  H Kusaka; S Matsumoto; T Imai
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

4.  Pick bodies in the locus ceruleus.

Authors:  L S Forno; L F Eng; D J Selkoe
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

5.  Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors.

Authors:  F J Doherty; N U Osborn; J A Wassell; P E Heggie; L Laszlo; R J Mayer
Journal:  Biochem J       Date:  1989-10-01       Impact factor: 3.857

6.  Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.

Authors:  G Lennox; J Lowe; M Landon; E J Byrne; R J Mayer; R B Godwin-Austen
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-11       Impact factor: 10.154

Review 7.  Diffuse Lewy body disease in Japan.

Authors:  K Kosaka
Journal:  J Neurol       Date:  1990-06       Impact factor: 4.849

8.  α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.

Authors:  Youngshin Lim; Victoria M Kehm; Edward B Lee; James H Soper; Chi Li; John Q Trojanowski; Virginia M-Y Lee
Journal:  J Neurosci       Date:  2011-07-06       Impact factor: 6.167

9.  New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies.

Authors:  P N Leigh; A Probst; G E Dale; D P Power; J P Brion; A Dodson; B H Anderton
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

10.  Clinicopathologic study of Alzheimer's disease: Alzheimer mimics.

Authors:  Yong S Shim; Catherine M Roe; Virginia D Buckles; John C Morris
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472
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