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Literature DB >> 6308771

Lewy bodies of Parkinson's disease contain neurofilament antigens.

J E Goldman, S H Yen, F C Chiu, N S Peress.

Abstract

The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.

Entities: Disease

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Year: 1983 PMID： 6308771 DOI： 10.1126/science.6308771

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

60 in total

1. A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene.

Authors: I V Mersiyanova; A V Perepelov; A V Polyakov; V F Sitnikov; E L Dadali; R B Oparin; A N Petrin; O V Evgrafov
Journal: Am J Hum Genet Date: 2000-06-07 Impact factor: 11.025

2. Relationships between Lewy bodies and pale bodies in Parkinson's disease.

Authors: G E Dale; A Probst; P Luthert; J Martin; B H Anderton; P N Leigh
Journal: Acta Neuropathol Date: 1992 Impact factor: 17.088

3. Filaments of Lewy bodies contain insoluble cytoskeletal elements.

Authors: P G Galloway; P Mulvihill; G Perry
Journal: Am J Pathol Date: 1992-04 Impact factor: 4.307

Review 4. The Lewy body in Parkinson's disease and related neurodegenerative disorders.

Authors: Koichi Wakabayashi; Kunikazu Tanji; Saori Odagiri; Yasuo Miki; Fumiaki Mori; Hitoshi Takahashi
Journal: Mol Neurobiol Date: 2012-05-24 Impact factor: 5.590

5. Ubiquitin and phosphorylated neurofilament epitopes in ballooned neurons of the extraocular muscle nuclei in a case of Werdnig-Hoffmann disease.

Authors: S Kato; A Hirano
Journal: Acta Neuropathol Date: 1990 Impact factor: 17.088

Lewy bodies of Parkinson's disease contain neurofilament antigens.

1. A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene.

2. Relationships between Lewy bodies and pale bodies in Parkinson's disease.

3. Filaments of Lewy bodies contain insoluble cytoskeletal elements.

Review 4. The Lewy body in Parkinson's disease and related neurodegenerative disorders.

5. Ubiquitin and phosphorylated neurofilament epitopes in ballooned neurons of the extraocular muscle nuclei in a case of Werdnig-Hoffmann disease.

Review 6. Inflammation and adaptive immunity in Parkinson's disease.

7. Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.

8. Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation.

9. New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies.

10. Intraneuronal dopamine-quinone synthesis: a review.