Literature DB >> 25400902

Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties.

Haoyu Tang1, Lichen Yin1, Kyung Hoon Kim1, Jianjun Cheng1.   

Abstract

Poly(arginine) mimics bearing long hydrophobic side chains adopt stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. They show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

Entities:  

Year:  2013        PMID： 25400902      PMCID： PMC4232443          DOI： 10.1039/C3SC51328A

Source DB:  PubMed          Journal:  Chem Sci        ISSN： 2041-6520            Impact factor:   9.825


  44 in total

1.  Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micelles.

Authors:  Paolo Ruzza; Andrea Calderan; Andrea Guiotto; Alessio Osler; Gianfranco Borin
Journal:  J Pept Sci       Date:  2004-07       Impact factor: 1.905

2.  Interaction of S413-PV cell penetrating peptide with model membranes: relevance to peptide translocation across biological membranes.

Authors:  Miguel Mano; Ana Henriques; Artur Paiva; Manuel Prieto; Francisco Gavilanes; Sérgio Simões; Maria C Pedroso de Lima
Journal:  J Pept Sci       Date:  2007-05       Impact factor: 1.905

3.  Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display.

Authors:  Betsy A Smith; Douglas S Daniels; Abigail E Coplin; Gregory E Jordan; Lynn M McGregor; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2008-02-14       Impact factor: 15.419

Review 4.  The design of guanidinium-rich transporters and their internalization mechanisms.

Authors:  Paul A Wender; Wesley C Galliher; Elena A Goun; Lisa R Jones; Thomas H Pillow
Journal:  Adv Drug Deliv Rev       Date:  2007-11-09       Impact factor: 15.470

5.  Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.

Authors:  Paul A Wender; Jonathan B Rothbard; Theodore C Jessop; Erik L Kreider; Bryan L Wylie
Journal:  J Am Chem Soc       Date:  2002-11-13       Impact factor: 15.419

6.  Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells.

Authors:  Erika I Geihe; Christina B Cooley; Jeff R Simon; Matthew K Kiesewetter; Justin A Edward; Robyn P Hickerson; Roger L Kaspar; James L Hedrick; Robert M Waymouth; Paul A Wender
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-30       Impact factor: 11.205

7.  Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency.

Authors:  Xin Zhao; Lichen Yin; Jieying Ding; Cui Tang; Shaohua Gu; Chunhua Yin; Yumin Mao
Journal:  J Control Release       Date:  2010-01-20       Impact factor: 9.776

8.  Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells.

Authors:  Carsten Rudolph; Christian Plank; James Lausier; Ulrike Schillinger; Rainer H Müller; Joseph Rosenecker
Journal:  J Biol Chem       Date:  2003-01-08       Impact factor: 5.157

9.  Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins.

Authors:  Brian R McNaughton; James J Cronican; David B Thompson; David R Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205

10.  Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect.

Authors:  Sandra Veldhoen; Sandra D Laufer; Alexander Trampe; Tobias Restle
Journal:  Nucleic Acids Res       Date:  2006-11-28       Impact factor: 16.971
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  26 in total

1.  Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure.

Authors:  Jonathan Yen; Lichen Yin; Jianjun Cheng
Journal:  J Mater Chem B       Date:  2014       Impact factor: 6.331

2.  A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction.

Authors:  Thomas E Speltz; Jeanne M Danes; Joshua D Stender; Jonna Frasor; Terry W Moore
Journal:  ACS Chem Biol       Date:  2018-01-24       Impact factor: 5.100

3.  Discovery and mechanistic characterization of a structurally-unique membrane active peptide.

Authors:  Shivani Bansal; Wan-Chih Su; Madhu Budamagunta; Wenwu Xiao; Yousif Ajena; Ruiwu Liu; John C Voss; Randy P Carney; Atul N Parikh; Kit S Lam
Journal:  Biochim Biophys Acta Biomembr       Date:  2020-06-18       Impact factor: 3.747

4.  Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity.

Authors:  Xiaojian Deng; Nan Zheng; Ziyuan Song; Lichen Yin; Jianjun Cheng
Journal:  Biomaterials       Date:  2014-03-24       Impact factor: 12.479

5.  Design of aromatic-containing cell-penetrating peptide mimics with structurally modified π electronics.

Authors:  Brittany M deRonde; Alexander Birke; Gregory N Tew
Journal:  Chemistry       Date:  2014-12-23       Impact factor: 5.236

Review 6.  Ionic α-helical polypeptides toward nonviral gene delivery.

Authors:  Rujing Zhang; Ziyuan Song; Lichen Yin; Nan Zheng; Haoyu Tang; Hua Lu; Nathan P Gabrielson; Yao Lin; Kyung Kim; Jianjun Cheng
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2014-11-06

Review 7.  Non-viral vectors for RNA delivery.

Authors:  Yi Yan; Xiao-Yu Liu; An Lu; Xiang-Yu Wang; Lin-Xia Jiang; Jian-Cheng Wang
Journal:  J Control Release       Date:  2022-01-10       Impact factor: 9.776

8.  The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides.

Authors:  Rujing Zhang; Nan Zheng; Ziyuan Song; Lichen Yin; Jianjun Cheng
Journal:  Biomaterials       Date:  2014-01-15       Impact factor: 12.479

9.  Polypeptides with quaternary phosphonium side chains: synthesis, characterization, and cell-penetrating properties.

Authors:  Ziyuan Song; Nan Zheng; Xiaochu Ba; Lichen Yin; Rujing Zhang; Liang Ma; Jianjun Cheng
Journal:  Biomacromolecules       Date:  2014-03-17       Impact factor: 6.988

10.  Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences.

Authors:  Jessica R Kramer; Nathan W Schmidt; Kristine M Mayle; Daniel T Kamei; Gerard C L Wong; Timothy J Deming
Journal:  ACS Cent Sci       Date:  2015-04-15       Impact factor: 14.553
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