Zhiyuan Wang1, Qichang Zhou2, Jun Liu3, Shichu Tang4, Xia Liang4, Zhengyu Zhou4, Ying He5, Hui Peng4, Yuanming Xiao6. 1. Department of Ultrasound, The Second Xiangya Hospital of Central South University Changsha 410011, China ; Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China. 2. Department of Ultrasound, The Second Xiangya Hospital of Central South University Changsha 410011, China. 3. Department of Radiology, The Second Xiangya Hospital of Central South University, The School of Public Administration of Central South University Changsha 410011, China. 4. Department of Ultrasound, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China. 5. Department of Breast Surgery, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, China. 6. Health Management Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
Abstract
PURPOSE: This study aimed to determine the role of breast invasive ductal cancer (BIDC) size measured with Contrast-enhanced Ultrasound (CEUS) in the prediction of regional lymph node metastasis (LNM) and N stage. METHODS: One hundred and six consecutive patients with breast lesions underwent ultrasound imaging within 2 weeks before mastectomy and axillary lymph node dissection. The largest transverse (width) and anteroposterior (depth) diameter were measured under CEUS by using calipers. The correlation between tumor size and regional LNM metastasis and N stage was evaluated. RESULTS: Univariate analysis showed the diameters measured with CEUS were associated with lymph node metastasis (P < 0.05). The tumor size could distinguish grouped N stage (all P < 0.05). Tumor area (TA) might be an indicator that can differentiate No BIDC from N1-3 BIDC (cutoff = 5.37 cm(2)), N0-1 BIDC from N2-3 BIDC (cutoff = 6.48 cm(2)), and N0-2 BIDC from N3 BIDC (cutoff = 8.23 cm(2)) with the sensitivity of 71%, 72% and 83%, respectively, and the specificity of 79%, 68% and 84%, respectively. CONCLUSIONS: The TA of BIDC measured with CEUS may be a predictor of regional LNM and N stage.
PURPOSE: This study aimed to determine the role of breast invasive ductal cancer (BIDC) size measured with Contrast-enhanced Ultrasound (CEUS) in the prediction of regional lymph node metastasis (LNM) and N stage. METHODS: One hundred and six consecutive patients with breast lesions underwent ultrasound imaging within 2 weeks before mastectomy and axillary lymph node dissection. The largest transverse (width) and anteroposterior (depth) diameter were measured under CEUS by using calipers. The correlation between tumor size and regional LNM metastasis and N stage was evaluated. RESULTS: Univariate analysis showed the diameters measured with CEUS were associated with lymph node metastasis (P < 0.05). The tumor size could distinguish grouped N stage (all P < 0.05). Tumor area (TA) might be an indicator that can differentiate No BIDC from N1-3 BIDC (cutoff = 5.37 cm(2)), N0-1 BIDC from N2-3 BIDC (cutoff = 6.48 cm(2)), and N0-2 BIDC from N3 BIDC (cutoff = 8.23 cm(2)) with the sensitivity of 71%, 72% and 83%, respectively, and the specificity of 79%, 68% and 84%, respectively. CONCLUSIONS: The TA of BIDC measured with CEUS may be a predictor of regional LNM and N stage.
Entities:
Keywords:
Breast invasive ductal cancer; N stage; contrast-enhanced ultrasound; lymph node metastasis
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