Xiaotong Hu1, Zhongting Huang2, Zhongcai Liao3, Chao He2, Xiao Fang4. 1. Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou 30016, Zhejiang, China. 2. Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou 30016, Zhejiang, China ; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 30016, Zhejiang, China. 3. Zhejiang Orient Gene Biotech Co., LTD Anji 313300, Zhejiang, China. 4. Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province Hangzhou 30016, Zhejiang, China ; Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 30016, Zhejiang, China.
Abstract
BACKGROUND: Carbonic anhydrase II is present in normal gastric mucosa; thus, this study aimed to investigate whether its expression persisted in neoplastic gastric tissues, as well as its prognostic value for gastric cancer patients. METHODS: The protein CA II expression pattern was retrospectively analyzed by immunohistochemistry in 181 gastric cancer patients who had undergone gastrectomy. The relationship between the CA II expression level and clinicopathological parameters was investigated. Survival analysis according to CA II expression was measured by Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of CA II expression. RESULTS: CA II expression was significantly decreased in gastric cancer tissues compared with normal stomach mucosa. Low expression was significantly associated with tumor size, depth of invasion, lymph node involvement, distant metastasis and TNM stage, and it predicted poor survival in gastric cancer patients. Moreover, CA II was an independent prognosis indicator for the overall survival of gastric cancer patients. CONCLUSIONS: The down-regulation of CA II expression was observed in gastric cancer and may serve as an independent prognostic factor for the overall survival of gastric cancer patients.
BACKGROUND:Carbonic anhydrase II is present in normal gastric mucosa; thus, this study aimed to investigate whether its expression persisted in neoplastic gastric tissues, as well as its prognostic value for gastric cancerpatients. METHODS: The protein CA II expression pattern was retrospectively analyzed by immunohistochemistry in 181 gastric cancerpatients who had undergone gastrectomy. The relationship between the CA II expression level and clinicopathological parameters was investigated. Survival analysis according to CA II expression was measured by Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of CA II expression. RESULTS:CA II expression was significantly decreased in gastric cancer tissues compared with normal stomach mucosa. Low expression was significantly associated with tumor size, depth of invasion, lymph node involvement, distant metastasis and TNM stage, and it predicted poor survival in gastric cancerpatients. Moreover, CA II was an independent prognosis indicator for the overall survival of gastric cancerpatients. CONCLUSIONS: The down-regulation of CA II expression was observed in gastric cancer and may serve as an independent prognostic factor for the overall survival of gastric cancerpatients.
Authors: S Ivanov; S Y Liao; A Ivanova; A Danilkovitch-Miagkova; N Tarasova; G Weirich; M J Merrill; M A Proescholdt; E H Oldfield; J Lee; J Zavada; A Waheed; W Sly; M I Lerman; E J Stanbridge Journal: Am J Pathol Date: 2001-03 Impact factor: 4.307
Authors: Anna D Wagner; Wilfried Grothe; Johannes Haerting; Gerhard Kleber; Axel Grothey; Wolfgang E Fleig Journal: J Clin Oncol Date: 2006-06-20 Impact factor: 44.544
Authors: Seppo Parkkila; Jerzy Lasota; Jonathan A Fletcher; Wen-Bin Ou; Antti J Kivelä; Kyösti Nuorva; Anna-Kaisa Parkkila; Jyrki Ollikainen; William S Sly; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; Jorma Isola; Markku Miettinen Journal: Mod Pathol Date: 2010-01-15 Impact factor: 7.842
Authors: Jonna Lehtonen; Bairong Shen; Mauno Vihinen; Angela Casini; Andrea Scozzafava; Claudiu T Supuran; Anna-Kaisa Parkkila; Juha Saarnio; Antti J Kivelä; Abdul Waheed; William S Sly; Seppo Parkkila Journal: J Biol Chem Date: 2003-11-04 Impact factor: 5.157
Authors: Minna Nortunen; Heikki Huhta; Olli Helminen; Seppo Parkkila; Joonas H Kauppila; Tuomo J Karttunen; Juha Saarnio Journal: Virchows Arch Date: 2018-07-31 Impact factor: 4.064
Authors: Tomas Tokar; Chiara Pastrello; Varune R Ramnarine; Chang-Qi Zhu; Kenneth J Craddock; Larrisa A Pikor; Emily A Vucic; Simon Vary; Frances A Shepherd; Ming-Sound Tsao; Wan L Lam; Igor Jurisica Journal: Oncotarget Date: 2018-01-08
Authors: M Lupu-Plesu; A Claren; S Martial; P-D N'Diaye; K Lebrigand; N Pons; D Ambrosetti; I Peyrottes; J Feuillade; J Hérault; M Dufies; J Doyen; G Pagès Journal: Oncogenesis Date: 2017-07-03 Impact factor: 7.485