Literature DB >> 12406565

The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer.

Whei Ling Chiang1, Shu Chen Chu, Shyh Sheng Yang, Mu Chun Li, Jyh Chang Lai, Shun Fa Yang, Hui Ling Chiou, Yih Shou Hsieh.   

Abstract

This study was designed to elucidate the possible relationship between the expression of cytosolic carbonic anhydrase (CA) and non-small cell lung cancer (NSCLC). The activity and protein expression patterns of carbonic anhydrase I (CAI) and II (CAII) of 70 NSCLC patients were analyzed by CA activity analysis, immunoblotting and immunohistochemical staining. The results showed that the CA activity and protein expression were significantly decreased in both squamous cell carcinoma (SCC) and adenocarcinoma (AD) (P<0.001 and P<0.001). From our study, it was suggested that the reduction of CAI and CAII in both SCC and AD patients may promote tumor cell motility and contribute to tumor growth and metastasis.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12406565     DOI： 10.1016/s0304-3835(02)00078-2

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  12 in total

1.  Low CA II expression is associated with tumor aggressiveness and poor prognosis in gastric cancer patients.

Authors:  Xiaotong Hu; Zhongting Huang; Zhongcai Liao; Chao He; Xiao Fang
Journal:  Int J Clin Exp Pathol       Date:  2014-09-15

2.  Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice.

Authors:  Nurdan Gönül Baltacı; Enver Fehim Koçpınar; Harun Budak
Journal:  Mol Biol Rep       Date:  2021-10-15       Impact factor: 2.316

3.  Reduction of CAII Expression in Gastric Cancer: Correlation with Invasion and Metastasis.

Authors:  Xiao-Jie Li; Hai-Long Xie; San-Ju Lei; Hui-Qiu Cao; Tian-Yun Meng; Yu-Lin Hu
Journal:  Chin J Cancer Res       Date:  2012-09       Impact factor: 5.087

4.  Differentially expressed and activated proteins associated with non small cell lung cancer tissues.

Authors:  E Nigro; E Imperlini; O Scudiero; M L Monaco; R Polito; G Mazzarella; S Orrù; A Bianco; A Daniele
Journal:  Respir Res       Date:  2015-06-24

5.  Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis.

Authors:  Wei-Chen Lee; Hong-Shiue Chou; Ting-Jung Wu; Chen-Fang Lee; Pao-Yueh Hsu; Hsiu-Ying Hsu; Tsung-Han Wu; Kun-Ming Chan
Journal:  Clin Proteomics       Date:  2017-08-02       Impact factor: 3.988

6.  Sera of patients with spontaneous tumour regression and elevated anti-CA I autoantibodies change the gene expression of ECM proteins.

Authors:  Jan Lakota; Radivojka Vulic; Maria Dubrovcakova; Silvia Tyciakova
Journal:  J Cell Mol Med       Date:  2016-10-05       Impact factor: 5.310

7.  A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells.

Authors:  Sina Ibne Noor; Somayeh Jamali; Samantha Ames; Silke Langer; Joachim W Deitmer; Holger M Becker
Journal:  Elife       Date:  2018-05-29       Impact factor: 8.140

8.  Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.

Authors:  Alzbeta Hulikova; Nicholas Aveyard; Adrian L Harris; Richard D Vaughan-Jones; Pawel Swietach
Journal:  J Biol Chem       Date:  2014-07-24       Impact factor: 5.157

9.  Sequenced Combinations of Cisplatin and Selected Phytochemicals towards Overcoming Drug Resistance in Ovarian Tumour Models.

Authors:  Safiah Ibrahim Althurwi; Jun Q Yu; Philip Beale; Fazlul Huq
Journal:  Int J Mol Sci       Date:  2020-10-12       Impact factor: 5.923

10.  New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators.

Authors:  Niccolò Chiaramonte; Alessio Gabellini; Andrea Angeli; Gianluca Bartolucci; Laura Braconi; Silvia Dei; Elisabetta Teodori; Claudiu T Supuran; Maria Novella Romanelli
Journal:  Molecules       Date:  2022-01-15       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.