Marieke T Blom1, Stefanie G Beesems1, Petronella C M Homma1, Jolande A Zijlstra1, Michiel Hulleman1, Daniel A van Hoeijen1, Abdennasser Bardai1, Jan G P Tijssen1, Hanno L Tan2, Rudolph W Koster1. 1. From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.T.B., S.G.B., P.C.M.H., J.A.Z., M.H., D.A.v.H., A.B., J.G.P.T., H.L.T., R.W.K.); Interuniversity Cardiology Institute Netherlands, Utrecht, The Netherlands (A.B.). 2. From the Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.T.B., S.G.B., P.C.M.H., J.A.Z., M.H., D.A.v.H., A.B., J.G.P.T., H.L.T., R.W.K.); Interuniversity Cardiology Institute Netherlands, Utrecht, The Netherlands (A.B.). h.l.tan@amc.uva.nl.
Abstract
BACKGROUND: In recent years, a wider use of automated external defibrillators (AEDs) to treat out-of-hospital cardiac arrest was advocated in The Netherlands. We aimed to establish whether survival with favorable neurologic outcome after out-of-hospital cardiac arrest has significantly increased, and, if so, whether this is attributable to AED use. METHODS AND RESULTS: We performed a population-based cohort study, including patients with out-of-hospital cardiac arrest from cardiac causes between 2006 and 2012, excluding emergency medical service-witnessed arrests. We determined survival status at each stage (to emergency department, to admission, and to discharge) and examined temporal trends using logistic regression analysis with year of resuscitation as an independent variable. By adding each covariable subsequently to the regression model, we investigated their impact on the odds ratio of year of resuscitation. Analyses were performed according to initial rhythm (shockable versus nonshockable) and AED use. Rates of survival with favorable neurologic outcome after out-of-hospital cardiac arrest increased significantly (N=6133, 16.2% to 19.7%; P for trend=0.021), although solely in patients presenting with a shockable initial rhythm (N=2823; 29.1% to 41.4%; P for trend<0.001). In this group, survival increased at each stage but was strongest in the prehospital phase (odds ratio, 1.11 [95% CI, 1.06-1.16]). Rates of AED use almost tripled during the study period (21.4% to 59.3%; P for trend <0.001), thereby decreasing time from emergency call to defibrillation-device connection (median, 9.9 to 8.0 minutes; P<0.001). AED use statistically explained increased survival with favorable neurologic outcome by decreasing the odds ratio of year of resuscitation to a nonsignificant 1.04. CONCLUSIONS: Increased AED use is associated with increased survival in patients with a shockable initial rhythm. We recommend continuous efforts to introduce or extend AED programs.
BACKGROUND: In recent years, a wider use of automated external defibrillators (AEDs) to treat out-of-hospital cardiac arrest was advocated in The Netherlands. We aimed to establish whether survival with favorable neurologic outcome after out-of-hospital cardiac arrest has significantly increased, and, if so, whether this is attributable to AED use. METHODS AND RESULTS: We performed a population-based cohort study, including patients with out-of-hospital cardiac arrest from cardiac causes between 2006 and 2012, excluding emergency medical service-witnessed arrests. We determined survival status at each stage (to emergency department, to admission, and to discharge) and examined temporal trends using logistic regression analysis with year of resuscitation as an independent variable. By adding each covariable subsequently to the regression model, we investigated their impact on the odds ratio of year of resuscitation. Analyses were performed according to initial rhythm (shockable versus nonshockable) and AED use. Rates of survival with favorable neurologic outcome after out-of-hospital cardiac arrest increased significantly (N=6133, 16.2% to 19.7%; P for trend=0.021), although solely in patients presenting with a shockable initial rhythm (N=2823; 29.1% to 41.4%; P for trend<0.001). In this group, survival increased at each stage but was strongest in the prehospital phase (odds ratio, 1.11 [95% CI, 1.06-1.16]). Rates of AED use almost tripled during the study period (21.4% to 59.3%; P for trend <0.001), thereby decreasing time from emergency call to defibrillation-device connection (median, 9.9 to 8.0 minutes; P<0.001). AED use statistically explained increased survival with favorable neurologic outcome by decreasing the odds ratio of year of resuscitation to a nonsignificant 1.04. CONCLUSIONS: Increased AED use is associated with increased survival in patients with a shockable initial rhythm. We recommend continuous efforts to introduce or extend AED programs.
Authors: Jason E Buick; Ian R Drennan; Damon C Scales; Steven C Brooks; Adams Byers; Sheldon Cheskes; Katie N Dainty; Michael Feldman; P Richard Verbeek; Cathy Zhan; Alex Kiss; Laurie J Morrison; Steve Lin Journal: Circ Cardiovasc Qual Outcomes Date: 2018-01
Authors: Eric Goralnick; Muhammad A Chaudhary; Justin C McCarty; Edward J Caterson; Scott A Goldberg; Juan P Herrera-Escobar; Meghan McDonald; Stuart Lipsitz; Adil H Haider Journal: JAMA Surg Date: 2018-09-01 Impact factor: 14.766
Authors: Steen Møller Hansen; Carolina Malta Hansen; Fredrik Folke; Shahzleen Rajan; Kristian Kragholm; Linda Ejlskov; Gunnar Gislason; Lars Køber; Thomas A Gerds; Søren Hjortshøj; Freddy Lippert; Christian Torp-Pedersen; Mads Wissenberg Journal: JAMA Cardiol Date: 2017-05-01 Impact factor: 14.676
Authors: Martin K Stiles; Arthur A M Wilde; Dominic J Abrams; Michael J Ackerman; Christine M Albert; Elijah R Behr; Sumeet S Chugh; Martina C Cornel; Karen Gardner; Jodie Ingles; Cynthia A James; Jyh-Ming Jimmy Juang; Stefan Kääb; Elizabeth S Kaufman; Andrew D Krahn; Steven A Lubitz; Heather MacLeod; Carlos A Morillo; Koonlawee Nademanee; Vincent Probst; Elizabeth V Saarel; Luciana Sacilotto; Christopher Semsarian; Mary N Sheppard; Wataru Shimizu; Jonathan R Skinner; Jacob Tfelt-Hansen; Dao Wu Wang Journal: Heart Rhythm Date: 2020-10-19 Impact factor: 6.343