A R Sanders1, E R Martin2, G W Beecham2, S Guo2, K Dawood3, G Rieger4, J A Badner5, E S Gershon5, R S Krishnappa6, A B Kolundzija7, J Duan1, P V Gejman1, J M Bailey8. 1. Department of Psychiatry and Behavioral Sciences,NorthShore University HealthSystem Research Institute,Evanston,IL,USA. 2. Department of Human Genetics,University of Miami,Miami,FL,USA. 3. Department of Psychology,Pennsylvania State University,University Park,PA,USA. 4. Department of Psychology,University of Essex,Colchester,England,UK. 5. Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Chicago,IL,USA. 6. Department of Psychiatry,Icahn School of Medicine at Mount Sinai,Elmhurst,NY,USA. 7. Department of Sociomedical Sciences,Mailman School of Public Health, Columbia University,New York,NY,USA. 8. Department of Psychology,Northwestern University,Evanston,IL,USA.
Abstract
BACKGROUND: Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD: We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. RESULTS: We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. CONCLUSIONS: Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.
BACKGROUND: Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD: We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. RESULTS: We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. CONCLUSIONS: Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.
Authors: Ashlyn Swift-Gallant; Lindsay A Coome; Madison Aitken; D Ashley Monks; Doug P VanderLaan Journal: Proc Natl Acad Sci U S A Date: 2019-06-10 Impact factor: 11.205
Authors: Andrea Ganna; Karin J H Verweij; John R B Perry; Benjamin M Neale; Brendan P Zietsch; Michel G Nivard; Robert Maier; Robbee Wedow; Alexander S Busch; Abdel Abdellaoui; Shengru Guo; J Fah Sathirapongsasuti; Paul Lichtenstein; Sebastian Lundström; Niklas Långström; Adam Auton; Kathleen Mullan Harris; Gary W Beecham; Eden R Martin; Alan R Sanders Journal: Science Date: 2019-08-30 Impact factor: 47.728