Literature DB >> 2539530

Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci.

S P Klinken1, J W Hartley, T N Fredrickson, U R Rapp, H C Morse.   

Abstract

The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait.

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Year:  1989        PMID： 2539530      PMCID： PMC250669     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS.

Authors:  F LILLY; E A BOYSE; L J OLD
Journal:  Lancet       Date:  1964-12-05       Impact factor: 79.321

2.  Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A.

Authors:  D Meruelo; M Offer; A Rossomando
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

3.  Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice.

Authors:  H C Morse; J W Hartley; T N Fredrickson; R A Yetter; C Majumdar; J L Cleveland; U R Rapp
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

4.  Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf.

Authors:  P Sutrave; T I Bonner; U R Rapp; H W Jansen; T Patschinsky; K Bister
Journal:  Nature       Date:  1984 May 3-9       Impact factor: 49.962

5.  Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus.

Authors:  U R Rapp; J L Cleveland; T N Fredrickson; K L Holmes; H C Morse; H W Jansen; T Patschinsky; K Bister
Journal:  J Virol       Date:  1985-07       Impact factor: 5.103

6.  Genetic control of sensitivity to Moloney leukemia virus in mice. II. Mapping of three resistant genes within the H-2 complex.

Authors:  P Debre; S Gisselbrecht; F Pozo; J P Levy
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

7.  Different genes control the susceptibility of mice to Moloney or Abelson murine leukemia viruses.

Authors:  R Risser; D Kaehler; W W Lamph
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

8.  Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

Authors:  D Meruelo; M Leiberman; N Ginzton; B Deak; H O McDevitt
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307

9.  Abelson virus-induced lymphomagenesis in mice.

Authors:  R Risser; M Potter; W P Rowe
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

10.  Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex.

Authors:  P Lonai; N Haran-Ghera
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307
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