| Literature DB >> 197197 |
Abstract
A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv-1 and H-2D. This localization and the complementation of the two loci for resistance are characteristics similar to Ir genes, and indicate a possible relationship between the genetic regulation of immune responsiveness and susceptibility to leukemia.Entities:
Mesh:
Substances:
Year: 1977 PMID: 197197 PMCID: PMC2180826 DOI: 10.1084/jem.146.4.1164
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307