Literature DB >> 2539176

Prognostic relevance of DNA content in childhood renal tumours.

S Kumar1, H B Marsden, R A Cowan, J M Barnes.   

Abstract

The DNA content of paraffin embedded tumour specimens from 100 children with kidney tumours was studied by flow cytometry. Data of adequate quality were obtained from 93 cases comprising 67 Wilms' tumours with a favourable histology (FH), 12 Wilms' tumours with unfavourable histology (UH) (pleomorphic), 8 bone-metastasising renal tumours of childhood (BMRTC) and 6 rhabdoid renal tumours. Only 4.5% FH compared with 75% UH Wilms' were aneuploid (P less than 0.001). Although BMRTC and rhabdoid tumours are associated with poor prognosis, there were no examples of aneuploidy in these tumours. The proliferation index was found to be of no prognostic value. Staging and ploidy were not correlated with each other in any of the various histological types of renal tumours studied.

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Year:  1989        PMID： 2539176      PMCID： PMC2247016          DOI： 10.1038/bjc.1989.60

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  29 in total

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Journal:  Cancer       Date:  1986-12-01       Impact factor: 6.860

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4.  DNA flow analysis of soft tissue tumors.

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Journal:  Cancer       Date:  1987-01-01       Impact factor: 6.860

5.  Well differentiated clear cell renal carcinoma: significance of nuclear deoxyribonucleic acid patterns studied by flow cytometry.

Authors:  L M Rainwater; Y Hosaka; G M Farrow; M M Lieber
Journal:  J Urol       Date:  1987-01       Impact factor: 7.450

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Authors:  D W Hedley; M L Friedlander; I W Taylor
Journal:  Cytometry       Date:  1985-07

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Authors:  H F Dvorak
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8.  Proliferative characteristics and ploidy of human brain tumors by DNA flow cytometry.

Authors:  M Danova; A Riccardi; G Mazzini; G Ucci; C M Montecucco; P Gaetani; V Silvani; R Knerich; G Butti; E Ascari
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Authors:  M L Friedlander; P Russell; I W Taylor; D W Hedley; M H Tattersall
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10.  Stromal metachromasia: a marker for areas of incipient invasion in ductal carcinoma of the breast?

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  6 in total

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Authors:  S Gururangan; A Dorman; R Ball; B Curran; M Leader; F Breatnach; A O'Meara
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Authors:  A O'Meara; S Gururangan; R Ball; E Kay; A Kelsey
Journal:  Urol Res       Date:  1993

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Authors:  D Lanigan; P A McLean; B Curran; M Leader
Journal:  J Clin Pathol       Date:  1993-02       Impact factor: 3.411

5.  Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.

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6.  A non-diploid DNA status is linked to poor prognosis in renal cell cancer.

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  6 in total

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