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Literature DB >> 2539174

High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.

P E Postmus¹, H Haaxma-Reiche, D T Sleijfer, A Kirkpatrick, J G McVie, J P Kleisbauer.

Abstract

Symptomatic brain metastases are found in about 40% of patients with small cell lung cancer. Cranial irradiation is the first line treatment for this form of metastatic disease. Frequently brain metastases recur after this treatment or develop after prophylactic cranial irradiation. For these patients no effective antitumour therapy is available. In this study the efficacy of high dose etoposide 1.5 g m-2 was evaluated. In 10 (43%) out of 23 evaluable patients a response was seen. Toxicity was severe with five aplasia-related deaths. For palliative purposes this regimen is too toxic in heavily pretreated patients.

Entities: Chemical Disease Species

Mesh：

Substances：
Etoposide

Year: 1989 PMID： 2539174 PMCID： PMC2246989 DOI： 10.1038/bjc.1989.52

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

1. CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival.

Authors: J L Nugent; P A Bunn; M J Matthews; D C Ihde; M H Cohen; A Gazdar; J D Minna
Journal: Cancer Date: 1979-11 Impact factor: 6.860

Review 2. Central nervous system metastases in small cell bronchogenic carcinoma.

Authors: P A Bunn; J L Nugent; M J Matthews
Journal: Semin Oncol Date: 1978-09 Impact factor: 4.929

3. Brain metastases from small cell lung cancer treated with combination chemotherapy.

Authors: P E Kristjansen; H H Hansen
Journal: Eur J Cancer Clin Oncol Date: 1988-03

4. Treatment of brain metastases of lung cancer with high doses of etoposide (VP16-213). Cooperative study from the Groupe Franais Pneumo-Cancérologie.

Authors: J P Kleisbauer; D Vesco; J Orehek; B Blaive; C Clary; R Poirier; S Saretto; P Carles; G Dongay; J C Guerin
Journal: Eur J Cancer Clin Oncol Date: 1988-02

5. Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.

Authors: M H Cohen; D C Ihde; P A Bunn; B E Fossieck; M J Matthews; S E Shackney; A Johnston-Early; R Makuch; J D Minna
Journal: Cancer Treat Rep Date: 1979-02

6. Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.

Authors: P E Postmus; J J Holthuis; H Haaxma-Reiche; N H Mulder; L M Vencken; W J van Oort; D T Sleijfer; H J Sluiter
Journal: J Clin Oncol Date: 1984-03 Impact factor: 44.544

7. Results of whole-brain irradiation for metastases from small cell carcinoma of the lung.

Authors: J D Cox; R Komaki; R W Byhardt; L E Kun
Journal: Cancer Treat Rep Date: 1980 Aug-Sep

8. Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung.

Authors: R J Baglan; J E Marks
Journal: Cancer Date: 1981-01-01 Impact factor: 6.860

9. High-dose etoposide for refractory malignancies: a phase I study.

Authors: P E Postmus; N H Mulder; D T Sleijfer; A F Meinesz; R Vriesendorp; E G de Vries
Journal: Cancer Treat Rep Date: 1984-12

10. Teniposide (VM26): an effective treatment for brain metastases of small cell carcinoma of the lung.

Authors: G Giaccone; M Donadio; G M Bonardi; F Testore; A Calciati
Journal: Eur J Cancer Clin Oncol Date: 1988-04

7 in total

1. Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases?

Authors: Pieter E Postmus; Egbert F Smit
Journal: J Thorac Dis Date: 2017-10 Impact factor: 2.895

High dose etoposide for brain metastases of small cell lung cancer. A phase II study. The EORTC Lung Cancer Cooperative Group.

1. CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival.

Review 2. Central nervous system metastases in small cell bronchogenic carcinoma.

3. Brain metastases from small cell lung cancer treated with combination chemotherapy.

4. Treatment of brain metastases of lung cancer with high doses of etoposide (VP16-213). Cooperative study from the Groupe Franais Pneumo-Cancérologie.

5. Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.

6. Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.

7. Results of whole-brain irradiation for metastases from small cell carcinoma of the lung.

8. Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung.

9. High-dose etoposide for refractory malignancies: a phase I study.

10. Teniposide (VM26): an effective treatment for brain metastases of small cell carcinoma of the lung.

1. Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases?

2. Resolution of small cell lung cancer intracranial metastases with standard dose chemotherapy.

3. Phase II trial of cisplatinum and etoposide in brain metastases of solid tumors.

Review 4. The role of chemotherapy in the treatment of patients with brain metastases from solid tumors.

5. Successful treatment of cranial metastases of extrapulmonary small cell carcinoma with chemotherapy alone.

6. Penetration of etoposide into human malignant brain tumors after intravenous and oral administration.

Review 7. Treatment options for small cell lung cancer - do we have more choice?