Literature DB >> 2539141

A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.

J K Juang1, H W Huang, C M Chen, H J Liu.   

Abstract

Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2539141     DOI： 10.1016/0006-291x(89)92226-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  The recognition of DNA cleavage sites by porcine spleen topoisomerase II.

Authors:  H W Huang; J K Juang; H J Liu
Journal:  Nucleic Acids Res       Date:  1992-02-11       Impact factor: 16.971

2.  Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins.

Authors:  Ting-Zhuo Lv; Guang-Shun Wang
Journal:  Exp Ther Med       Date:  2015-05-07       Impact factor: 2.447

3.  Withaferin A targets heat shock protein 90 in pancreatic cancer cells.

Authors:  Yanke Yu; Adel Hamza; Tao Zhang; Mancang Gu; Peng Zou; Bryan Newman; Yanyan Li; A A Leslie Gunatilaka; Chang-Guo Zhan; Duxin Sun
Journal:  Biochem Pharmacol       Date:  2010-02-15       Impact factor: 5.858

4.  Brine shrimp cytotoxicity of crude methanol extract and antispasmodic activity of α-amyrin acetate from Tylophora hirsuta wall.

Authors:  Niaz Ali
Journal:  BMC Complement Altern Med       Date:  2013-06-17       Impact factor: 3.659
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.