| Literature DB >> 25388579 |
Nathalie Delgehyr1, Nathalie Spassky1.
Abstract
The primary cilium is often associated with the phases G0 and G1 of the cellular cycle in most of the cells. So, recent studies show that its formation and its resorption are closely linked to molecular actors of the cellular cycle, as for example Aurora A or PLK1 (polo-like kinase 1). Furthermore, its resorption seems to be critical for the progress of the phase S and the cellular determination, in particular in the case of neural stem cells. Finally, the primary cilium acts as a cellular antenna allowing to transmit numerous signal pathways which, in their turn, contribute to the cellular fate.Entities:
Mesh:
Substances:
Year: 2014 PMID: 25388579 DOI: 10.1051/medsci/20143011011
Source DB: PubMed Journal: Med Sci (Paris) ISSN: 0767-0974 Impact factor: 0.818