J Huang1, C Ding, X Chen, R He, N Chen. 1. Physical Examination Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Abstract
OBJECTIVES: To investigate the potential association of TGF-β1 -509C/T (rs1800469), +869T/C (rs1800470), and +915G/C (rs1800471) polymorphisms with susceptibility to periodontitis. MATERIALS AND METHODS: Several electronic databases were searched for eligible articles. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were calculated to assess the strength of relationship between the TGF-β1 polymorphisms and periodontitis risk. RESULTS: Eleven studies were searched without any language restriction. Pooled estimates showed that TGF-β1 -509C/T polymorphism was associated with decreased risk of periodontitis. Subgroup analysis revealed that -509C/T T allele was associated with decreased risk of chronic periodontitis (CP) in Asians (T allele vs C allele: OR = 0.81, 95% CI = 0.69-0.97, Pheterogeneity = 0.25). Furthermore, the +915G/C CC genotype might be associated with elevated risk of CP in Caucasians (CC vs GG: OR = 9.14, 95% CI = 1.01-82.50, Pheterogeneity = 0.49). Concerning +869T/C polymorphism, no evidence of significant association was identified. CONCLUSION: This meta-analysis suggested that TGF-β1 -509C/T T allele was associated with decreased risk of CP in Asians, while +915G/C CC genotype might contribute to increased CP risk in Caucasians. Replication studies of our results in independent large populations are necessary to validate this association in diverse populations.
OBJECTIVES: To investigate the potential association of TGF-β1 -509C/T (rs1800469), +869T/C (rs1800470), and +915G/C (rs1800471) polymorphisms with susceptibility to periodontitis. MATERIALS AND METHODS: Several electronic databases were searched for eligible articles. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were calculated to assess the strength of relationship between the TGF-β1 polymorphisms and periodontitis risk. RESULTS: Eleven studies were searched without any language restriction. Pooled estimates showed that TGF-β1 -509C/T polymorphism was associated with decreased risk of periodontitis. Subgroup analysis revealed that -509C/T T allele was associated with decreased risk of chronic periodontitis (CP) in Asians (T allele vs C allele: OR = 0.81, 95% CI = 0.69-0.97, Pheterogeneity = 0.25). Furthermore, the +915G/C CC genotype might be associated with elevated risk of CP in Caucasians (CC vs GG: OR = 9.14, 95% CI = 1.01-82.50, Pheterogeneity = 0.49). Concerning +869T/C polymorphism, no evidence of significant association was identified. CONCLUSION: This meta-analysis suggested that TGF-β1 -509C/T T allele was associated with decreased risk of CP in Asians, while +915G/C CC genotype might contribute to increased CP risk in Caucasians. Replication studies of our results in independent large populations are necessary to validate this association in diverse populations.