Literature DB >> 25385109

Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia.

Jean Popovici1, Sokheng Kao1, Leanghor Eal1, Sophalai Bin1, Saorin Kim1, Didier Ménard2.   

Abstract

Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri province. These preliminary data should encourage additional studies for associating artemisinin or chloroquine resistance and K12 polymorphism.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25385109      PMCID： PMC4291442          DOI： 10.1128/AAC.03908-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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