Literature DB >> 18938106

Recent highlights in antimalarial drug resistance and chemotherapy research.

David A Fidock1, Richard T Eastman, Stephen A Ward, Steven R Meshnick.   

Abstract

This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters on this topic that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008 (MAM 2008). After surveying this area of research, we focus on two important questions: what is the molecular contribution of pfcrt to chloroquine resistance, and what is the mechanism of action of artemisinin? We conclude with thoughts about the current state of antimalarial chemotherapy and priorities moving forward.

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Year:  2008        PMID： 18938106      PMCID： PMC2718548          DOI： 10.1016/j.pt.2008.09.005

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  89 in total

1.  Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function.

Authors:  J Alfredo Bonilla; Tonya D Bonilla; Charles A Yowell; Hisashi Fujioka; John B Dame
Journal:  Mol Microbiol       Date:  2007-07       Impact factor: 3.501

Review 2.  New antimalarial targets: the example of glucose transport.

Authors:  Asha Parbhu Patel; Henry M Staines; Sanjeev Krishna
Journal:  Travel Med Infect Dis       Date:  2008-03-07       Impact factor: 6.211

3.  No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance.

Authors:  Nanhua Chen; Qi Gao; Shanqing Wang; Guangze Wang; Michelle Gatton; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2007-10-22       Impact factor: 5.191

4.  Potent antimalarial activity of histone deacetylase inhibitor analogues.

Authors:  K T Andrews; T N Tran; A J Lucke; P Kahnberg; G T Le; G M Boyle; D L Gardiner; T S Skinner-Adams; D P Fairlie
Journal:  Antimicrob Agents Chemother       Date:  2008-01-22       Impact factor: 5.191

5.  Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Authors:  Tina S Skinner-Adams; Jonathan Lowther; Franka Teuscher; Colin M Stack; Jolanta Grembecka; Artur Mucha; Pawel Kafarski; Katharine R Trenholme; John P Dalton; Donald L Gardiner
Journal:  J Med Chem       Date:  2007-10-26       Impact factor: 7.446

Review 6.  Coenzyme A biosynthesis: an antimicrobial drug target.

Authors:  Christina Spry; Kiaran Kirk; Kevin J Saliba
Journal:  FEMS Microbiol Rev       Date:  2008-01       Impact factor: 16.408

7.  Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

Authors:  David J Johnson; Andrew Owen; Nick Plant; Patrick G Bray; Stephen A Ward
Journal:  Antimicrob Agents Chemother       Date:  2008-01-14       Impact factor: 5.191

8.  Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.

Authors:  Giancarlo A Biagini; Nicholas Fisher; Neil Berry; Paul A Stocks; Brigitte Meunier; Dominic P Williams; Richard Bonar-Law; Patrick G Bray; Andrew Owen; Paul M O'Neill; Stephen A Ward
Journal:  Mol Pharmacol       Date:  2008-03-04       Impact factor: 4.436

9.  Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum.

Authors:  Nectarios Klonis; Olivia Tan; Katherine Jackson; Daniel Goldberg; Michael Klemba; Leann Tilley
Journal:  Biochem J       Date:  2007-11-01       Impact factor: 3.857

10.  Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Authors:  Paul Hunt; Ana Afonso; Alison Creasey; Richard Culleton; Amar Bir Singh Sidhu; John Logan; Stephanie G Valderramos; Iain McNae; Sandra Cheesman; Virgilio do Rosario; Richard Carter; David A Fidock; Pedro Cravo
Journal:  Mol Microbiol       Date:  2007-07       Impact factor: 3.501
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  26 in total

1.  Plasmodium falciparum ATP6 not under selection during introduction of artemisinin combination therapy in Peru.

Authors:  Charles J Woodrow; Leyla Y Bustamante
Journal:  Antimicrob Agents Chemother       Date:  2010-05       Impact factor: 5.191

2.  Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.

Authors:  Shengxin Cai; April L Risinger; Shalini Nair; Jiangnan Peng; Timothy J C Anderson; Lin Du; Douglas R Powell; Susan L Mooberry; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2015-12-21       Impact factor: 4.050

Review 3.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

4.  In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.

Authors:  Lara Liv Bajohr; Ling Ma; Christian Platte; Oliver Liesenfeld; Lutz F Tietze; Uwe Gross; Wolfgang Bohne
Journal:  Antimicrob Agents Chemother       Date:  2009-11-02       Impact factor: 5.191

5.  A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

Authors:  Gustavo A Afanador; Alfredo J Guerra; Russell P Swift; Ryan E Rodriguez; David Bartee; Krista A Matthews; Arne Schön; Ernesto Freire; Caren L Freel Meyers; Sean T Prigge
Journal:  Mol Microbiol       Date:  2017-09-08       Impact factor: 3.501

6.  Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.

Authors:  Gustavo A Afanador; Krista A Matthews; David Bartee; Jolyn E Gisselberg; Maroya S Walters; Caren L Freel Meyers; Sean T Prigge
Journal:  Mol Microbiol       Date:  2014-09-01       Impact factor: 3.501

7.  Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia.

Authors:  Jean Popovici; Sokheng Kao; Leanghor Eal; Sophalai Bin; Saorin Kim; Didier Ménard
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

8.  Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.

Authors:  Stephanie Gaw Valderramos; Daniel Scanfeld; Anne-Catrin Uhlemann; David A Fidock; Sanjeev Krishna
Journal:  Antimicrob Agents Chemother       Date:  2010-06-21       Impact factor: 5.191

9.  Inferred relatedness and heritability in malaria parasites.

Authors:  Tim J C Anderson; Jeff T Williams; Shalini Nair; Daniel Sudimack; Marion Barends; Anchalee Jaidee; Ric N Price; François Nosten
Journal:  Proc Biol Sci       Date:  2010-04-14       Impact factor: 5.349

10.  Cytoadherence of erythrocytes invaded by Plasmodium falciparum: quantitative contact-probing of a human malaria receptor.

Authors:  P A Carvalho; M Diez-Silva; H Chen; M Dao; S Suresh
Journal:  Acta Biomater       Date:  2013-01-29       Impact factor: 8.947
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