Literature DB >> 25382682

Cerebral blood flow and cognitive function in patients with metabolic syndrome: effect of antihypertensive therapy.

Irina Efimova1, Natalya Efimova, Yuri Lishmanov.   

Abstract

The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.
Copyright © 2014 Wiley Periodicals, Inc.

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Year:  2014        PMID： 25382682      PMCID： PMC8031927          DOI： 10.1111/jch.12435

Source DB:  PubMed          Journal:  J Clin Hypertens (Greenwich)        ISSN： 1524-6175            Impact factor:   3.738


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