Literature DB >> 25379594

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou-Pong Pau, Janet M McNicholl, Yungtai Lo, Betsy C Herold, Ryan Teller, Patrick Kiser, James M Smith.   

Abstract

BACKGROUND AND METHODS: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. RESULTS AND
CONCLUSIONS: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

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Year:  2014        PMID： 25379594      PMCID： PMC4226177          DOI： 10.1111/jmp.12119

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  26 in total

1.  Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings.

Authors:  R Karl Malcolm; A David Woolfson; Clare F Toner; Ryan J Morrow; Stephen D McCullagh
Journal:  J Antimicrob Chemother       Date:  2005-09-09       Impact factor: 5.790

2.  Contraceptive vaginal ring use for women has less adverse metabolic effects than an oral contraceptive.

Authors:  Karen E Elkind-Hirsch; Carmen Darensbourg; Beverly Ogden; Lauren F Ogden; Philip Hindelang
Journal:  Contraception       Date:  2007-09-27       Impact factor: 3.375

3.  Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.

Authors:  Susan M Fetherston; Leslie Geer; Ronald S Veazey; Laurie Goldman; Diarmaid J Murphy; Thomas J Ketas; Per Johan Klasse; Sylvain Blois; Paolo La Colla; John P Moore; R Karl Malcolm
Journal:  J Antimicrob Chemother       Date:  2012-10-28       Impact factor: 5.790

4.  Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide.

Authors:  A David Woolfson; R Karl Malcolm; Ryan J Morrow; Clare F Toner; Stephen D McCullagh
Journal:  Int J Pharm       Date:  2006-06-23       Impact factor: 5.875

5.  Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.

Authors:  James M Smith; Rachna Rastogi; Ryan S Teller; Priya Srinivasan; Pedro M M Mesquita; Umadevi Nagaraja; Janet M McNicholl; R Michael Hendry; Chuong T Dinh; Amy Martin; Betsy C Herold; Patrick F Kiser
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

6.  Dilution assessment of cervicovaginal secretions obtained by vaginal washing for immunological assays.

Authors:  L Bélec; D Meillet; M Lévy; A Georges; C Tévi-Bénissan; J Pillot
Journal:  Clin Diagn Lab Immunol       Date:  1995-01

7.  Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques.

Authors:  John A Moss; Amanda M Malone; Thomas J Smith; Irina Butkyavichene; Cassandra Cortez; Joshua Gilman; Sean Kennedy; Etana Kopin; Cali Nguyen; Preetha Sinha; R Michael Hendry; Patricia Guenthner; Angela Holder; Amy Martin; Janet McNicholl; James Mitchell; Chou-Pong Pau; Priya Srinivasan; James M Smith; Marc M Baum
Journal:  Antimicrob Agents Chemother       Date:  2012-09-10       Impact factor: 5.191

8.  Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1.

Authors:  Kavita M Gupta; Serena M Pearce; Azadeh E Poursaid; Hyder A Aliyar; Patrick A Tresco; Mark A Mitchnik; Patrick F Kiser
Journal:  J Pharm Sci       Date:  2008-10       Impact factor: 3.534

9.  Effect of mobile phase pH and organic content on LC-MS analysis of nucleoside and nucleotide HIV reverse transcriptase inhibitors.

Authors:  Zsuzsanna Kuklenyik; Amy Martin; Chou-Pong Pau; J Gerardo Garcia-Lerma; Walid Heneine; James L Pirkle; John R Barr
Journal:  J Chromatogr Sci       Date:  2009 May-Jun       Impact factor: 1.618

10.  An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.

Authors:  Rachel Singer; Paul Mawson; Nina Derby; Aixa Rodriguez; Larisa Kizima; Radhika Menon; Daniel Goldman; Jessica Kenney; Meropi Aravantinou; Samantha Seidor; Agegnehu Gettie; James Blanchard; Michael Piatak; Jeffrey D Lifson; José A Fernández-Romero; Melissa Robbiani; Thomas M Zydowsky
Journal:  Sci Transl Med       Date:  2012-09-05       Impact factor: 17.956
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  8 in total

1.  A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates.

Authors:  Jonathan T Su; Ryan S Teller; Priya Srinivasan; Jining Zhang; Amy Martin; Samuel Sung; James M Smith; Patrick F Kiser
Journal:  Pharm Res       Date:  2017-08-02       Impact factor: 4.200

2.  Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial.

Authors:  Marla J Keller; Lianna Wood; James M Billingsley; Laurie L Ray; Jessica Goymer; Shada Sinclair; Aileen P McGinn; Mark A Marzinke; Bruce Frank; Sujatha Srinivasan; Congzhou Liu; Jessica M Atrio; Lilia Espinoza; Nelly Mugo; Hans M L Spiegel; Peter L Anderson; David N Fredricks; Craig W Hendrix; Jeanne Marrazzo; Steven E Bosinger; Betsy C Herold
Journal:  Lancet HIV       Date:  2019-07-15       Impact factor: 12.767

3.  Pharmacokinetics of the Protein Microbicide 5P12-RANTES in Sheep following Single-Dose Vaginal Gel Administration.

Authors:  John W McBride; Nicola Dias; David Cameron; Robin E Offord; Oliver Hartley; Peter Boyd; Vicky L Kett; R Karl Malcolm
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

4.  Repeated administration of high-dose depot medroxyprogesterone acetate does not alter SHIVSF162p3 viral kinetics and tenofovir pharmacokinetics when delivered via intravaginal rings.

Authors:  Priya Srinivasan; Jining Zhang; Chuong T Dinh; Ryan S Teller; Janet M McNicholl; Patrick F Kiser; Betsy C Herold; James M Smith
Journal:  J Med Primatol       Date:  2017-08       Impact factor: 0.667

5.  Safety and Pharmacokinetics of Quick-Dissolving Polymeric Vaginal Films Delivering the Antiretroviral IQP-0528 for Preexposure Prophylaxis.

Authors:  Priya Srinivasan; Jining Zhang; Amy Martin; Kristin Kelley; Janet M McNicholl; Robert W Buckheit; James M Smith; Anthony S Ham
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

6.  Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques.

Authors:  Lara E Pereira; Pedro M M Mesquita; Anthony Ham; Tyana Singletary; Frank Deyounks; Amy Martin; Janet McNicholl; Karen W Buckheit; Robert W Buckheit; James M Smith
Journal:  Antimicrob Agents Chemother       Date:  2015-12-14       Impact factor: 5.191

Review 7.  Recent Advances in the Excipients Used in Modified Release Vaginal Formulations.

Authors:  Aikaterini Dedeloudi; Angeliki Siamidi; Panagoula Pavlou; Marilena Vlachou
Journal:  Materials (Basel)       Date:  2022-01-03       Impact factor: 3.623

Review 8.  Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.

Authors:  Fernando Notario-Pérez; Roberto Ruiz-Caro; María-Dolores Veiga-Ochoa
Journal:  Drug Des Devel Ther       Date:  2017-06-15       Impact factor: 4.162
  8 in total

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