Literature DB >> 25377566

Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.

Jagan Sundaram1, Usha R Pendurthi1, Charles T Esmon2, L Vijaya Mohan Rao1.   

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Year:  2014        PMID： 25377566      PMCID： PMC4467861          DOI： 10.1182/blood-2014-09-600254

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


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  10 in total

1.  The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.

Authors:  Giulia Pavani; Lacramioara Ivanciu; Armida Faella; Oscar A Marcos-Contreras; Paris Margaritis
Journal:  Blood       Date:  2014-06-23       Impact factor: 22.113

Review 2.  Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.

Authors:  L Vijaya Mohan Rao; Charles T Esmon; Usha R Pendurthi
Journal:  Blood       Date:  2014-07-21       Impact factor: 22.113

3.  Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

Authors:  W Li; X Zheng; J Gu; J Hunter; G L Ferrell; F Lupu; N L Esmon; C T Esmon
Journal:  J Thromb Haemost       Date:  2005-07       Impact factor: 5.824

Review 4.  Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.

Authors:  Usha R Pendurthi; L Vijaya Mohan Rao
Journal:  Thromb Res       Date:  2010-02-14       Impact factor: 3.944

5.  Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium.

Authors:  Samit Ghosh; Usha R Pendurthi; Anne Steinoe; Charles T Esmon; L Vijaya Mohan Rao
Journal:  J Biol Chem       Date:  2007-02-27       Impact factor: 5.157

6.  Multifunctional specificity of the protein C/activated protein C Gla domain.

Authors:  Roger J S Preston; Eva Ajzner; Cristina Razzari; Stalo Karageorgi; Sonia Dua; Björn Dahlbäck; David A Lane
Journal:  J Biol Chem       Date:  2006-07-25       Impact factor: 5.157

7.  The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

Authors:  D J Stearns-Kurosawa; S Kurosawa; J S Mollica; G L Ferrell; C T Esmon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

8.  Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

Authors:  J López-Sagaseta; R Montes; C Puy; N Díez; K Fukudome; J Hermida
Journal:  J Thromb Haemost       Date:  2007-09       Impact factor: 5.824

9.  Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications.

Authors:  Ramesh C Nayak; Prosenjit Sen; Samit Ghosh; Ramakrishnan Gopalakrishnan; Charles T Esmon; Usha R Pendurthi; L Vijaya Mohan Rao
Journal:  Blood       Date:  2009-07-08       Impact factor: 22.113

10.  The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis.

Authors:  Yang Buyue; Herbert C Whinna; John P Sheehan
Journal:  Blood       Date:  2008-07-22       Impact factor: 22.113
  10 in total
  8 in total

1.  Pharmacological concentrations of recombinant factor VIIa restore hemostasis independent of tissue factor in antibody-induced hemophilia mice.

Authors:  S Keshava; J Sundaram; A Rajulapati; U R Pendurthi; L V M Rao
Journal:  J Thromb Haemost       Date:  2016-02-15       Impact factor: 5.824

2.  Targeting platelet EPCR for better therapeutic factor VIIa activity.

Authors:  S X Gu; S R Lentz
Journal:  J Thromb Haemost       Date:  2018-08-03       Impact factor: 5.824

3.  Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.

Authors:  A M Fager; K R Machlus; M Ezban; M Hoffman
Journal:  J Thromb Haemost       Date:  2018-06-27       Impact factor: 5.824

4.  Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1.

Authors:  Vijay Kondreddy; Jue Wang; Shiva Keshava; Charles T Esmon; L Vijaya Mohan Rao; Usha R Pendurthi
Journal:  Blood       Date:  2018-04-18       Impact factor: 22.113

5.  Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: Mode of its action.

Authors:  Shiva Keshava; Jagan Sundaram; Anuradha Rajulapati; Charles Esmon; Usha Pendurthi; L Vijaya Mohan Rao
Journal:  Blood Adv       Date:  2017-06-27

6.  EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.

Authors:  Jhansi Magisetty; Usha R Pendurthi; Charles T Esmon; L Vijaya Mohan Rao
Journal:  Blood       Date:  2020-06-18       Impact factor: 22.113

7.  Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect.

Authors:  Kaushik Das; Shiva Keshava; Shabbir A Ansari; Vijay Kondreddy; Charles T Esmon; John H Griffin; Usha R Pendurthi; L Vijaya Mohan Rao
Journal:  Blood       Date:  2021-06-17       Impact factor: 25.476

8.  A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis.

Authors:  Vijay Kondreddy; Shiva Keshava; Charles T Esmon; Usha R Pendurthi; L Vijaya Mohan Rao
Journal:  Sci Rep       Date:  2020-11-25       Impact factor: 4.379
  8 in total

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