Literature DB >> 20156643

Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.

Usha R Pendurthi1, L Vijaya Mohan Rao.   

Abstract

Plasma coagulation factor VIIa (FVIIa) initiates the coagulation cascade by binding to its cofactor, tissue factor (TF) on cell surfaces, which eventually leads to fibrin deposition and platelet activation. Recent studies showed that FVIIa also binds to endothelial cell protein C receptor (EPCR), a known cellular receptor for anticoagulant protein C\activated protein C, on the endothelium. The present article reviews our current knowledge of FVIIa interaction with EPCR and discusses the potential significance of this interaction in hemostasis, treatment of bleeding disorders with pharmacological doses of FVIIa and FVIIa clearance. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20156643      PMCID： PMC2838982          DOI： 10.1016/j.thromres.2010.01.026

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  31 in total

1.  Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow.

Authors:  Alejandro B Balazs; Attila J Fabian; Charles T Esmon; Richard C Mulligan
Journal:  Blood       Date:  2005-11-22       Impact factor: 22.113

2.  Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

Authors:  W Li; X Zheng; J Gu; J Hunter; G L Ferrell; F Lupu; N L Esmon; C T Esmon
Journal:  J Thromb Haemost       Date:  2005-07       Impact factor: 5.824

Review 3.  Tissue factor-factor VIIa signaling.

Authors:  L Vijaya Mohan Rao; Usha R Pendurthi
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-11-29       Impact factor: 8.311

4.  Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium.

Authors:  Samit Ghosh; Usha R Pendurthi; Anne Steinoe; Charles T Esmon; L Vijaya Mohan Rao
Journal:  J Biol Chem       Date:  2007-02-27       Impact factor: 5.157

5.  Multifunctional specificity of the protein C/activated protein C Gla domain.

Authors:  Roger J S Preston; Eva Ajzner; Cristina Razzari; Stalo Karageorgi; Sonia Dua; Björn Dahlbäck; David A Lane
Journal:  J Biol Chem       Date:  2006-07-25       Impact factor: 5.157

6.  Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation.

Authors:  Clemens Feistritzer; Matthias Riewald
Journal:  Blood       Date:  2004-12-30       Impact factor: 22.113

7.  The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Authors:  Jong-Sup Bae; Likui Yang; Chandrashekhara Manithody; Alireza R Rezaie
Journal:  Blood       Date:  2007-09-06       Impact factor: 22.113

Review 8.  The use of recombinant factor VIIa in the treatment of bleeding disorders.

Authors:  Harold R Roberts; Dougald M Monroe; Gilbert C White
Journal:  Blood       Date:  2004-08-24       Impact factor: 22.113

9.  Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

Authors:  J López-Sagaseta; R Montes; C Puy; N Díez; K Fukudome; J Hermida
Journal:  J Thromb Haemost       Date:  2007-09       Impact factor: 5.824

10.  Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation.

Authors:  Lee A O'Brien; Mark A Richardson; Sean F Mehrbod; David T Berg; Bruce Gerlitz; Akanksha Gupta; Brian W Grinnell
Journal:  Arterioscler Thromb Vasc Biol       Date:  2007-10-11       Impact factor: 8.311
View more
  7 in total

1.  Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor.

Authors:  Mario C Rico; James J Rough; Joanne M Manns; Fabiola Del Carpio-Cano; Fayez F Safadi; Satya P Kunapuli; Raul A DeLa Cadena
Journal:  Thromb Res       Date:  2011-09-01       Impact factor: 3.944

2.  Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.

Authors:  Jagan Sundaram; Usha R Pendurthi; Charles T Esmon; L Vijaya Mohan Rao
Journal:  Blood       Date:  2014-11-06       Impact factor: 22.113

Review 3.  Protease-activated receptor signalling by coagulation proteases in endothelial cells.

Authors:  Alireza R Rezaie
Journal:  Thromb Haemost       Date:  2014-07-03       Impact factor: 5.249

Review 4.  Protein C anticoagulant and cytoprotective pathways.

Authors:  John H Griffin; Berislav V Zlokovic; Laurent O Mosnier
Journal:  Int J Hematol       Date:  2012-04-05       Impact factor: 2.490

Review 5.  Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.

Authors:  L Vijaya Mohan Rao; Charles T Esmon; Usha R Pendurthi
Journal:  Blood       Date:  2014-07-21       Impact factor: 22.113

6.  Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells.

Authors:  Ashley L DuMont; Nicholas P Cianciotto
Journal:  Infect Immun       Date:  2017-11-17       Impact factor: 3.441

7.  Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa.

Authors:  C A Clark; R Vatsyayan; U Hedner; C T Esmon; U R Pendurthi; L V M Rao
Journal:  J Thromb Haemost       Date:  2012-11       Impact factor: 5.824
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.