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Literature DB >> 2537694

The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver.

G Skolnik¹, U Bagge, G Blomqvist, L Djärv, H Ahlman.

Abstract

The effect of blockade of calcium channels and/or 5-HT receptors on the hepatic lodgement of intraportally injected fibrosarcoma cells was studied in rats. The calcium channel blocker verapamil and the 5-HT2 antagonist ketanserin each had a significant lodgement reducing effect. The pure 5-HT2 antagonist R 56413 was most effective and dose-dependent in its tumour cell lodgement reducing effect. At the highest dose tested (2.5 mg/kg body weight) R 56413 was as effective as thrombocytopenia, indicating that 5-HT is the most important platelet-released product that influences tumour cell lodgement.

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Year: 1989 PMID： 2537694 DOI： 10.1007/bf01787021

Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150

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7. Inhibition of rabbit platelet phosphodiesterase activity and aggregation by calcium channel blockers.

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8. The importance of 5-HT for tumor cell lodgement in the liver.

Authors: G Skolnik; U Bagge; A Dahlström; H Ahlman
Journal: Int J Cancer Date: 1984-04-15 Impact factor: 7.396

9. Increase in blood serotonin levels in the hepatic venous outflow after intraportal tumour cell injection.

Authors: G Blomqvist; G Skolnik; A Dahlström; H Ahlman
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10. The effect of thrombocytopenia and antiserotonin treatment on the lodgement of circulating tumor cells. A vital fluorescence microscopic, electron microscopic and isotope study in the rat.

Authors: G Skolnik; L E Ericson; U Bagge
Journal: J Cancer Res Clin Oncol Date: 1983 Impact factor: 4.553

5 in total

1. A comparison between morphological, rheological and lodgement properties of rat fibrosarcoma cells harvested from solid tumours and cultures.

Authors: U Nannmark; B R Johansson; U Bagge
Journal: Clin Exp Metastasis Date: 1991 Mar-Apr Impact factor: 5.150