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Literature DB >> 21258396

Contribution of platelets to tumour metastasis.

Laurie J Gay¹, Brunhilde Felding-Habermann.

Abstract

Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21258396 PMCID： PMC6894505 DOI： 10.1038/nrc3004

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

168 in total

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