OBJECTIVES/HYPOTHESIS: Definitive tissue diagnosis for lesions warranting biopsy is shifting from the operating room to the office. Safety, tolerance, factors related to successful biopsy, and time to treatment are not well-defined. METHODS: Retrospective review of 116 patients undergoing in-office biopsy of oropharynx, larynx, or hypopharynx were included. Logistic regression determined if demographics, site, T-stage, or approach (transoral/transnasal) were related to success. Time to definitive treatment was also analyzed. RESULTS: Ninety-two transnasal and 24 transoral biopsies were performed on 73 laryngeal, 35 oropharyngeal, and 8 hypopharyngeal lesions. Of those, 97 of 116 diagnoses were made in-office. There were no complications; two patients did not tolerate the procedure. Success was not related to age (P = 0.374), site (P = 0.527), T-stage (P = 0.587), or approach (P = 0.566). Time to treatment was 24.2 ± 13.9 days with successful office biopsy and 48.8 ± 49.4 days without. CONCLUSIONS: High procedural completion rate was observed across patients, sites, and approaches. All patients should be considered for in-office biopsy, a more time- and cost-effective option leading to earlier treatment.
OBJECTIVES/HYPOTHESIS: Definitive tissue diagnosis for lesions warranting biopsy is shifting from the operating room to the office. Safety, tolerance, factors related to successful biopsy, and time to treatment are not well-defined. METHODS: Retrospective review of 116 patients undergoing in-office biopsy of oropharynx, larynx, or hypopharynx were included. Logistic regression determined if demographics, site, T-stage, or approach (transoral/transnasal) were related to success. Time to definitive treatment was also analyzed. RESULTS: Ninety-two transnasal and 24 transoral biopsies were performed on 73 laryngeal, 35 oropharyngeal, and 8 hypopharyngeal lesions. Of those, 97 of 116 diagnoses were made in-office. There were no complications; two patients did not tolerate the procedure. Success was not related to age (P = 0.374), site (P = 0.527), T-stage (P = 0.587), or approach (P = 0.566). Time to treatment was 24.2 ± 13.9 days with successful office biopsy and 48.8 ± 49.4 days without. CONCLUSIONS: High procedural completion rate was observed across patients, sites, and approaches. All patients should be considered for in-office biopsy, a more time- and cost-effective option leading to earlier treatment.
Authors: David J Wellenstein; Joey K de Witt; Henrieke W Schutte; Jimmie Honings; Frank J A van den Hoogen; Henri A M Marres; Robert P Takes; Guido B van den Broek Journal: Eur Arch Otorhinolaryngol Date: 2017-06-21 Impact factor: 2.503
Authors: Francisco Lee; Kristine A Smith; Shamir Chandarana; T Wayne Matthews; J Douglas Bosch; Steven C Nakoneshny; Joseph C Dort Journal: J Otolaryngol Head Neck Surg Date: 2018-05-09
Authors: Henrieke W Schutte; Guido B van den Broek; Stefan C A Steens; Rosella P M G Hermens; Jimmie Honings; Henri A M Marres; Matthias A W Merkx; Willem L J Weijs; Anne I J Arens; Adriana C H van Engen-van Grunsven; Carla M L van Herpen; Johannes H A M Kaanders; Frank J A van den Hoogen; Robert P Takes Journal: Cancer Date: 2020-07-07 Impact factor: 6.860
Authors: David J Wellenstein; Jimmie Honings; Anouk S Schimberg; Henrieke W Schutte; Jasmijn M Herruer; Frank J A van den Hoogen; Robert P Takes; Guido B van den Broek Journal: Laryngoscope Date: 2019-09-09 Impact factor: 3.325