Jian Jun Wu1, Yu Jin2, Na Lin3, Zhi Ping Xie3, Jie Mei Yu3, Jin Song Li3, Chang Qing Cao1, Xin Hui Yuan1, Jin Rong Song1, Jing Zhang1, Yang Zhao1, Xiao Qian Gao1, Zhao Jun Duan3. 1. School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China. 2. School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu, China. 3. National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Abstract
OBJECTIVE: The aim of this study was to explore the prevalent characteristics of HBoV1 and its co-infection. METHODS: PCR was used to detect HBoV1-DNA (HBoV1) and other viruses. A multivariate logistic regression model was used to explore possibility of co-detected for related viruses. RESULTS: The positivity rates in Nanjing and Lanzhou were 9.38% (74/789) and 11.62% (161/1386), respectively (P>0.05). The HBoV1 positive group was younger than negative group (P<0.05). Seasonal differences were noted, with a higher frequency of infection in December and July. HBoV1-positive children [72.34% (169/235)] were co-infected with other respiratory viruses. Multifactorial analysis showed no correlations between HBoV1 and the clinical classification, region, gender, age, or treatment as an outpatient or in a hospital. Correlations were identified between HBoV1 infections with ADV (OR=1.53, 95% CI 1.03-2.28), RSV (OR=0.71, 95% CI 0.52-0.98), and IFVA (OR=1.77, 95% CI 1.00-3.13). CONCLUSION: Presence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender, although the prevalence of HBoV1 was higher in younger children. There were no correlations between HBoV1 and other variables, except for the season and ADV, RSV, or IFVA infections.
OBJECTIVE: The aim of this study was to explore the prevalent characteristics of HBoV1 and its co-infection. METHODS: PCR was used to detect HBoV1-DNA (HBoV1) and other viruses. A multivariate logistic regression model was used to explore possibility of co-detected for related viruses. RESULTS: The positivity rates in Nanjing and Lanzhou were 9.38% (74/789) and 11.62% (161/1386), respectively (P>0.05). The HBoV1 positive group was younger than negative group (P<0.05). Seasonal differences were noted, with a higher frequency of infection in December and July. HBoV1-positive children [72.34% (169/235)] were co-infected with other respiratory viruses. Multifactorial analysis showed no correlations between HBoV1 and the clinical classification, region, gender, age, or treatment as an outpatient or in a hospital. Correlations were identified between HBoV1 infections with ADV (OR=1.53, 95% CI 1.03-2.28), RSV (OR=0.71, 95% CI 0.52-0.98), and IFVA (OR=1.77, 95% CI 1.00-3.13). CONCLUSION: Presence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender, although the prevalence of HBoV1 was higher in younger children. There were no correlations between HBoV1 and other variables, except for the season and ADV, RSV, or IFVA infections.
Authors: Emily T Martin; Mary P Fairchok; Jane Kuypers; Amalia Magaret; Danielle M Zerr; Anna Wald; Janet A Englund Journal: J Infect Dis Date: 2010-06-01 Impact factor: 5.226
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