Long Tan1, Zhongna Sang1, Jun Shen2, Hua Liu3, Wen Chen1, Na Zhao1, Wei Wei4, Guiqin Zhang5, Wanqi Zhang1. 1. 1Department of Nutrition and Food Science,School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China. 2. 2Department of Sanitary Chemistry,School of Public Health,Tianjin Medical University,Tianjin,People's Republic of China. 3. 3Centers for Disease Control and Prevention in Cangzhou City,Cangzhou,People's Republic of China. 4. 4Chengyang Workstation of Health Supervision and Diseases Control,Qingdao,People's Republic of China. 5. 5Department of Clinical Nutrition,Binzhou Medical University Hospital,Binzhou,People's Republic of China.
Abstract
OBJECTIVE: To explore (i) the prevalence of thyroid dysfunction in populations with adequate and excessive iodine intakes and (ii) the effect of iodine exposure on the prevalence of thyroid dysfunction. DESIGN: Cross-sectional study was conducted in Hebei in 2010. The population was classified as having adequate or excessive iodine intake according to the iodine concentration in drinking water. Demographic information was collected by questionnaire. Levels of serum thyroid hormones, thyroid autoantibodies and iodine in drinking water and urine were measured. SETTING: Villages with adequate or excessive drinking water iodine in Hebei Province, People's Republic of China. SUBJECTS: A total of 854 men and women aged 20-50 years who had lived in the surveyed areas for over 5 years, including 348 from the adequate iodine area (AIA) and 506 from the excessive iodine area (EIA). RESULTS: Median urinary iodine concentration was 185 μg/l in AIA and 1152 μg/l in EIA. The prevalence of thyroid dysfunction in AIA was 10.3%, which included 1.1% with hypothyroidism and 8.1% with subclinical hypothyroidism; and 20.6% in EIA, which included 3.6% with hypothyroidism and 13.6% with subclinical hypothyroidism. The positive rates of thyroglobulin antibody were 16.1% in AIA and 11.9% in EIA; the positive rates of thyroperoxidase antibody were 20.7% in AIA and 16.4% in EIA. CONCLUSIONS: Excessive iodine intake may lead to increased prevalence of biochemical thyroid dysfunction, especially biochemical hypothyroidism. This is not related to an increase in prevalence of thyroid antibodies. Women are more susceptible to iodine excess.
OBJECTIVE: To explore (i) the prevalence of thyroid dysfunction in populations with adequate and excessive iodine intakes and (ii) the effect of iodine exposure on the prevalence of thyroid dysfunction. DESIGN: Cross-sectional study was conducted in Hebei in 2010. The population was classified as having adequate or excessive iodine intake according to the iodine concentration in drinking water. Demographic information was collected by questionnaire. Levels of serum thyroid hormones, thyroid autoantibodies and iodine in drinking water and urine were measured. SETTING: Villages with adequate or excessive drinking wateriodine in Hebei Province, People's Republic of China. SUBJECTS: A total of 854 men and women aged 20-50 years who had lived in the surveyed areas for over 5 years, including 348 from the adequate iodine area (AIA) and 506 from the excessive iodine area (EIA). RESULTS: Median urinary iodine concentration was 185 μg/l in AIA and 1152 μg/l in EIA. The prevalence of thyroid dysfunction in AIA was 10.3%, which included 1.1% with hypothyroidism and 8.1% with subclinical hypothyroidism; and 20.6% in EIA, which included 3.6% with hypothyroidism and 13.6% with subclinical hypothyroidism. The positive rates of thyroglobulin antibody were 16.1% in AIA and 11.9% in EIA; the positive rates of thyroperoxidase antibody were 20.7% in AIA and 16.4% in EIA. CONCLUSIONS: Excessive iodine intake may lead to increased prevalence of biochemical thyroid dysfunction, especially biochemical hypothyroidism. This is not related to an increase in prevalence of thyroid antibodies. Women are more susceptible to iodine excess.
Authors: Peter N Taylor; Diana Albrecht; Anna Scholz; Gala Gutierrez-Buey; John H Lazarus; Colin M Dayan; Onyebuchi E Okosieme Journal: Nat Rev Endocrinol Date: 2018-03-23 Impact factor: 43.330
Authors: Sofia Manousou; Maja Stål; Robert Eggertsen; Michael Hoppe; Lena Hulthén; Helena Filipsson Nyström Journal: Environ Health Prev Med Date: 2019-12-07 Impact factor: 3.674