Penipyrols A-B and peniamidones A-D from the mangrove derived Penicillium solitum GWQ-143.

Chemical investigation the extract of Penicillium solitum GWQ-143 led to yield four new compounds penipyrols A-B (1-2) and peniamidones A-B (3-4), together with peniamidones C-D (5-6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1-6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 μM.