Literature DB >> 25369424

Dilated hearts at high altitude: words from on high.

Harvey V Lankford1, Erik R Swenson.   

Abstract

From the time of the turn of the twentieth century, dilated hearts and presumed cardiac fatigue in expeditionary climbers and scientists have been the subject of much commentary in the medical and mountaineering literature. Although largely attributed by most, but not all, to left heart strain, the description of dilated hearts in these accounts is clearly that of right heart dilation as a consequence of high and sustained hypoxic pulmonary vasoconstriction with hypertensive remodeling. This essay will feature quotations from the writings of high altitude pioneers about dilated, strained, or enlarged hearts. It will give some brief physiology of the right side of the heart as background, but will focus on the words of mountaineers and mountaineering physicians as color commentary.

Entities:  

Keywords:  Everest; altitude; cor pulmonale; dilated; heart; pulmonary; ventricle

Mesh:

Year:  2014        PMID: 25369424     DOI: 10.1089/ham.2014.1047

Source DB:  PubMed          Journal:  High Alt Med Biol        ISSN: 1527-0297            Impact factor:   1.981


  5 in total

1.  Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.

Authors:  Rachel Zarndt; Stanley M Walls; Karen Ocorr; Rolf Bodmer
Journal:  Circ Cardiovasc Genet       Date:  2017-10

2.  Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under high-altitude hypoxia.

Authors:  Bo Zhang; Dongmei Ban; Xiao Gou; Yawen Zhang; Lin Yang; Yangzom Chamba; Hao Zhang
Journal:  J Anim Sci Biotechnol       Date:  2019-02-05

3.  Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers.

Authors:  Camilla Udjus; Ivar Sjaastad; Ulla Hjørnholm; Torbjørn K Tunestveit; Pavel Hoffmann; Alexis Hinojosa; Emil K S Espe; Geir Christensen; Ole H Skjønsberg; Karl-Otto Larsen; Morten Rostrup
Journal:  Physiol Rep       Date:  2022-02

4.  A change of heart: Mechanisms of cardiac adaptation to acute and chronic hypoxia.

Authors:  Alexandra M Williams; Benjamin D Levine; Mike Stembridge
Journal:  J Physiol       Date:  2022-08-28       Impact factor: 6.228

5.  Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay.

Authors:  Uday Yanamandra; Vasu Vardhan; Puneet Saxena; Priyanka Singh; Amul Gupta; Deepak Mulajkar; Rajan Grewal; Velu Nair
Journal:  Indian J Crit Care Med       Date:  2021-06
  5 in total

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